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| Articles
by
M. Helal U. Biswas |
Total Records (
2 ) for
M. Helal U. Biswas |
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M. Zakir Sultan
,
Zakia Sultana Sathi
,
M. Helal U. Biswas
,
M. Akteruzzaman Choudury
,
M. Aziz Abdur Rahman
and
M.A. Gafur
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The ethyl acetate extract of yeast extract-glucose broth medium of an Actinomycete strain, Streptomyces yielded three active metabolites C-1, C-2 and C-3, among which C-3 was identified as 2-N-butanamide-3-methyl-4-methoxy-5-β-L-arabinosyl-propanophenone on the basis of spectral data. The cytotoxic activity of the crude ethyl acetate extract and compound 1, 2 and 3 were determined by brine shrimp lethality bioassay. The compounds showed lower LC50 values indicating that these compounds were significantly cytotoxic. The LC50 of the crude ethyl acetate extract, C-1, C-2, C-3 and standard ampicillin trihydrate were 6.69, 12.30, 4.67, 6.62 and 10.28 μg ml-1 respectively. |
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M. Shah Alam Bhuiyan
,
Yuji Ito
,
Naotaka Tanaka
,
Golam Sadik
,
Kiyotaka Fujita
,
Atsuko Nakamura
,
M. Helal U. Biswas
,
Hiroshi Fukui
and
Kaoru Takegawa
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In order to obtain more insights into the molecular mechanisms of action of polyene
antibiotics in yeast cells, a number of nystatin sensitive mutants of Saccharomyces
cerevisiae were isolated by ethylmethane sulfonate mutagenesis. The mutants
were characterized in terms of their sensitivity test to stresses such as high
temperature or high concentration of monovalent and divalent cations. The invertase
overlay assay method suggests that some of these mutants are defective for vacuolar
protein sorting. By tetrad analysis four of these mutants were found to possesses
single gene mutation. |
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