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Articles by M. Golam Sadik
Total Records ( 2 ) for M. Golam Sadik
  M. Zakir Sultan , Naznin Ara Khatune , Zakia Sultana Sathi , Md. Shah Alam Bhuiyan , M. Golam Sadik , M. Akteruzzaman Choudury , M. A. Gafur and Md. Aziz Abdur Rahman
  The ethyl acetate extract of yeast extract-glucose broth medium of an Actinomycetes strain, Streptomyces yielded a reddish yellow antibiotic metabolite by chromatographic technique and was identified as 2 N-butanamide 3-methyl 4-methoxy 5-β-L-arabinosyl propanophenone (MZ-4) on the basis of spectral data. The compound exhibited significant antibacterial activity against five gram positive and nine gram negative bacteria when compared with standard Kanamycin antibiotic. The zone of inhibition were observed between 17 to 20 mm. The minimum inhibitory concentration (MIC) of the compound was determined against four gram positive and gram negative bacteria and the values were found between 32 and 64 μg ml-1.
  Bytul M. Rahman , M.S.A. Bhuiyan , M. Golam Sadik and A.S.M. Anisuzzman
  The sub-acute toxicity study of 3,6-dimethyl-4-ethyl-0-acetyl benzene (BM-5), was carried out on Long Evan’s rats using daily administration (300 μg/rat/day) of compound for 14 consecutive days. Non-significant differences between weight of compound receiving rats and control rats (48±0.816 vs 46±0.816) were found. The change in hematological parameters was found to be nonsignificant (total count of RBC, 5.1±0.081 vs 4.63±0.094; white blood cell, 7.33±0.124 vs 5.73±0.124; platelets, 361666±10274 vs 261666±8498, (cell/ml) x106; percentage of hemoglobin 65.67±1.60 vs 56±0.816; ESR, 25±0.816 vs 19.67±0.471 for experimental and control rats, respectively) and biochemical parameters (serum glutamate pyruvate transaminase, 8.5±0.408 vs 8.33 ±0.471 IU L-1; serum glutamate oxaloacetate transaminase, 9.83±0.235 vs 9.33±0.234 IU L-1; bilirubin, 0.36±0.104 vs 0.34±0.016 μg dL-1; creatinine, 0.67 ±0.089 vs 0.61±0.009 mg dL-1; urea, 18.83±0.235 vs 18.5±0.408 mg dL-1; for experimental and control rats). Therefore, the changes in body weight, hematological and biochemical parameters were statistically non-significant. No detectable abnormalities were found in histopathology of heart, kidney, liver and lung in experimental group of rats as compared with that of the control group of rats.
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