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Articles by M. Bahgat
Total Records ( 2 ) for M. Bahgat
  O.M. Ahmed , R.G. Ahmed , M.M.S. Nada and M. Bahgat
  Because the heat stress is one of the most stressful factors on the biological systems, it was important to study its effect on the development of neurons in different Central Nervous System (CNS) regions of albino rat newborns. Development of neurons in cerebral cortex, cerebellar cortex and cervical and lumbar regions of the spinal cord was followed by using Golgi-copsch stain between days 7 and 21 after birth. The present study does not only illustrate the aspects of development processes of normal neurons in different regions of CNS, but also records the effects of heat stress (40±1°C) on them. The present study revealed that the development of the CNS is extremely sensitive to heat stress which led, in turn, to some harmful effects on the neurons development and caused delay of the dendritic arborization in all investigated CNS regions of the rat newborns. Taken together, further studies are required to determine if the beneficial effects of heat exposure result in changes of stress complications only or not. Thus, experiments will be required to solve these problems and to comprehend the actual role of heatstroke in neurodegeneration of CNS.
  Osama M. Ahmed , M. Bahgat and R.G. Ahmed
  The normal monoamine [norepinephrine (NE), epinephrine (E), dopamine (DA) and serotonin (5-HT)] contents and cholinestrase (chE) activity were significantly and gradually increased with age progress between postnatal days 7 and 21 in cerebrum, cerebellum, medulla oblongata and spinal cord of rat newborns. The daily exposure of the newborns to 40±1°C for 2 h induced deteriorated effects and the withdrawal period of 7 days failed to return these altered variables to normal levels. On the other hand, the high temperature exerted its most potent decreased effect on monoamine contents at 21 days old. This decrease may be attributed to the elevated activity of monoamine oxidase and/or the decreased activity of the key enzymes responsible for monoamine synthesis. The chE activity exhibited different effects in the tested CNS regions as a result of high temperature exposure; the enzyme activity was decreased markedly at days 7, 14 and 21 in cerebellum and medulla oblongata and lowered only at days 7 and 14 in cerebrum and at day 14 in spinal cord. The subsequent withdrawal for 7 days beyond day 21 produced marked weakening of effect of high temperature exposure on monoamine contents in all examined CNS regions except NE and 5-HT contents in cerebellum and DA level in medulla oblongata. In spite of this attenuation, the values recorded in the withdrawal group were still significantly lower than the normal levels. On the other hand, the chE activity became more deleteriously affected at day 28 in the treated CNS regions except in the medulla oblongata where it was profoundly ameliorated after the withdrawal period.
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