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Articles by M. Aris Widodo
Total Records ( 2 ) for M. Aris Widodo
  Wahyu Widowati , Laura Wijaya , Dwi Agustina , Harry Murti , Nurul Fauziah , Sutiman B. Sumitro , M. Aris Widodo and Indra Bachtiar
  Cancer is one of the leading causes of mortality and morbidity throughout the world. Since there are still some problems related to the conventional therapies for cancer treatment, it is critical to explore new more efficient therapy strategies. Mesenchymal Stem Cells (MSCs) are one of powerful tools for tissue engineering for regenerative medicine, as recent research aims to utilize MSCs for anti-cancer treatment. Our previous research demonstrated that Conditioned Medium from Whartons’ Jelly MSCs (WJ-MSCs-CM) significantly lowered cancer proliferation of various cancer cell lines. This research was performed to evaluate the tumoricidal property of cell lysate from WJ-MSCs from normoxia (WJMSCs-norCL) and hypoxia-treated WJMSCs (WJMSCs-hypoCL) on the proliferation of human cancer cells, including cervical (HeLa), liver (HepG2), ovarian (SKOV3) and oral squamous (HSC3) cancer cell lines compared to normal cells including mouse fibroblast (NIH3T3), human Mesenchymal Stem Cells (hMSCs), human fibroblast. The WJMSCs-norCL and WJMSCs-hypoCL have cytotoxic activity, reduce proliferation of various cancer cell lines with minimum inhibitory concentration (IC50) 21.094-95.928 μg mL–1 and no cytotoxic to normal cells with IC50 409, 191-629, 799.738 μg mL–1. The WJMSCs-norCL and WJMSCs-hypoCL inhibit proliferation in various cancer cell lines and are not toxic for normal cells.
  Nurlaili Susanti , Choirun Nissa , Salwin N. Serina , Retty Ratnawati , Nurdiana , Sutiman B. Sumitro , Djoko W. Soeatmadji , Umi Kalsum , M. Aris Widodo and Simon B. Widjanarko
  Dietary fiber from glucomannan has been studied to decrease blood glucose concentration, but its mechanism in diabetes is still unclear. The aim of our research is to study the effect of glucomannan, derived from konjac flour, in rat models of diabetes including gastrointestinal function, inhibition of DPP-IV enzyme and reducing in insulin resistance. A total of 25 male wistar rats were divided into 5 groups; normal group (Normal), diabetes group (DM), diabetes group administered with 100 mg/kg BW konjac flour (DM+KF1), 200 mg/kg BW konjac flour (DM+KF2) and 400 mg/kg BW konjac flour (DM+KF3). Diabetes was induced by a combination of 60% high fructose diet and twice intraperitoneal injection of streptozotocin (25 and 30 mg/kg BW) at one week interval. Konjac flour was given according to each dose for 4 weeks. At the end of the study, blood and tissue sample were collected for subsequent analysis, while isolated intestine used to measure jejunal serous glucose concentration using everted sac technique. The results indicate that glucomannan reduced fasting blood glucose levels, improved glucose tolerance, increased jejunal serous glucose concentration at in vitro technique and decreased insulin resistance as evidenced by a decreased in HOMA-IR index and increased in PI3K levels. However, glucomannan not decreased DPP-4 levels in any dose. This results indicate that glucomannan derived from Konjac flour had antidiabetic effects through improving in glucose homeostasis and reducing in insulin resistance in rat models of diabetes.
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