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Articles by M. Akteruzzaman Choudury
Total Records ( 3 ) for M. Akteruzzaman Choudury
  M. Zakir Sultan , Naznin Ara Khatune , Zakia Sultana Sathi , Md. Shah Alam Bhuiyan , M. Golam Sadik , M. Akteruzzaman Choudury , M. A. Gafur and Md. Aziz Abdur Rahman
  The ethyl acetate extract of yeast extract-glucose broth medium of an Actinomycetes strain, Streptomyces yielded a reddish yellow antibiotic metabolite by chromatographic technique and was identified as 2 N-butanamide 3-methyl 4-methoxy 5-β-L-arabinosyl propanophenone (MZ-4) on the basis of spectral data. The compound exhibited significant antibacterial activity against five gram positive and nine gram negative bacteria when compared with standard Kanamycin antibiotic. The zone of inhibition were observed between 17 to 20 mm. The minimum inhibitory concentration (MIC) of the compound was determined against four gram positive and gram negative bacteria and the values were found between 32 and 64 μg ml-1.
  M. Zakir Sultan , Z. Sultana Sathi , M. Shah Alam Bhuiyan , M. Akteruzzaman Choudury , M. Helal Uddin Biswas , M.A. Gafur and M. Aziz Abdur Rahman
  The ethyl acetate extract of yeast extract-glucose broth medium of an Actinomycetes strain, Streptomyces yielded a reddish yellow metabolite by chromatographic technique and was identified as 2-N-butanamide-3-methyl-4-methoxy-5-β-L-arabinosyl-propanophenone (MZ-4) on the basis of spectral data. The sub-acute toxicity study of this metabolite was carried out on long Evan`s rats. The change of haematological and biochemical parameters were statistically insignificant. No abnormalities were found in the histopathology of the liver, kidneys, heart, lungs and spleen in the experimental group of rats at a dose of 300 μg rat-1 day-1 for 14 consecutive days, when compared with the control group.
  M. Zakir Sultan , Zakia Sultana Sathi , M. Helal U. Biswas , M. Akteruzzaman Choudury , M. Aziz Abdur Rahman and M.A. Gafur
  The ethyl acetate extract of yeast extract-glucose broth medium of an Actinomycete strain, Streptomyces yielded three active metabolites C-1, C-2 and C-3, among which C-3 was identified as 2-N-butanamide-3-methyl-4-methoxy-5-β-L-arabinosyl-propanophenone on the basis of spectral data. The cytotoxic activity of the crude ethyl acetate extract and compound 1, 2 and 3 were determined by brine shrimp lethality bioassay. The compounds showed lower LC50 values indicating that these compounds were significantly cytotoxic. The LC50 of the crude ethyl acetate extract, C-1, C-2, C-3 and standard ampicillin trihydrate were 6.69, 12.30, 4.67, 6.62 and 10.28 μg ml-1 respectively.
 
 
 
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