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Articles by M. Akrami
Total Records ( 2 ) for M. Akrami
  Alizadeh Shaban , S.A. Jahanmehr , M. Rezaeeian , N. Einolahi , A. Arjomand , H.R. Monsefesfehani , V. Kazemi and M. Akrami
  Cancer is the second leading cause of death worldwide. Conventional therapies cause serious side effects and, at best, merely extend the patient’s lifespan by a few years. Cancer control may therefore benefit from the potential that resides in alternative therapies. There is thus an increasing demand to utilize alternative concepts or approaches to the prevention of cancer. The antineoplastic effect of Trigonella foenum graecum seed extract has been evaluated in human acute T Lymphoblastic leukemia cell lines (CCRF-HSB-2). After determination of toxic level of fenugreek seeds extract on each cell lines, them were treated with different doses of extract and after incubation time (24 and 48 h) results were evaluated by cell count, viability test, staining and light microscopy and finally were analyzed in term of apoptosis induction using annexin v-fitc flowcytometry kit. Then data were analyzed using SPSS 11.5 software. Results show significant effects of Fenugreek seeds extract against this cell line such as growth inhibition, cell death and morphological change. Apoptosis induction by this extract in these cell lines was little. Fenugreek seeds extract didn’t change the count and morphology of normal lymphocytes. These findings suggest significant antineoplastic effects of Fenugreek seeds against CCRF-HSB-2 cell line. A strategy to selectively induce apoptosis of leukemia cells without altering healthy cells is a major goal for the development of new therapeutic techniques. To our knowledge, this is the first study that suggests significant chemo preventive effects of Fenugreek seeds against these cell lines.
  M. Akrami , As. Ibrahimov , E. Valizadeh and Abolfazl Asadi Dizaji
  In this investigation, the ability of nine Trichoderma harzianum isolates which had been isolated from soil and root rapeseed field were compared to one isolate of Bacillus subtilis and 2 per thousand benomyl solution to control rapeseed sclorotinia rot. These isolates had shown good control of Sclerotinia sclerotiorum in in vitro condition. In this experiment seed of Talaye variety were planted in pots of 15 cm diameter and offer seedling emergence they were thined to one seedling. The plants were maintained at 20±2°C and 90% R.H until flowerbuds appeared. After flowerbud appearance the plants were inoculated with 7mm diameter mycelium disk put on low, middle and uppear leaf of each plant. The controls were treated with 107 mL 1 of spores of the antagonist fungus, a 108 mL 1 bacterial suspension and with a 2 per thousand benomyl solution separated at 2 different times. One set of control plants were treated 3 days ahead of inoculation and another set were treated on the same day. Assessment of the inhibitory effect of treatment on fungal pathogen were done 3 days after inoculation of the leaves by measuring the diameter of the lesions produced and comparing with sterile water control. The results obtained show that: there is a significant difference between the biological treatment agents. The shortest diameter of the lesions on inoculated plants belonged to T1 and T3 isolates of T. harzianum and also to B. subtilis. There was no significant difference between T4 and B. subtilis in other word, use of any of these three would have same effect. The two isolates T1 and T9 of T. harzianum and B. subtilis when used at the same time that plants are inoculated with the pathogen would have the most effect. Comparing the bonomyl effect with that of biological agents, it had significantly superior effect. The position of the leaf on the plant had not significant effect.
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