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Articles by M. Akhter Farooque
Total Records ( 2 ) for M. Akhter Farooque
  M. Saidul Islam , M. Akhter Farooque and M.A.K. Bodruddoza
  New complex of Cu+2 ion with Schiff base derived from the condensation of m-aminophenol with o-hydroxybenzaldehyde has been synthesized. The complex has the formulae [Cu(L)(NN)]. The complex was characterized on the basis of elemental analyses, melting points, conductance and magnetic measurements, infra-red and electronic spectra. The physico-chemical studies suggest a square planar structure for Cu+2 complex. Antineoplastic activity of this complex has been carried out. The antineoplastic activity of the complex was carried out on Swiss Albino male mice.
  M. Shamim Hossain , M. Aslam Hossain , R. Islam , A. H. M. Khurshid Alam , Kudrat-e-Zahan , S. Sarkar and M. Akhter Farooque
  Owing to the biological importance of metalloelements in many biological processes, especially metabolic processes, magnesium(II) complexes were synthesized and examined for their antimicrobial and cytotoxic activities. Among the two synthesized organometalic complexes [Mg(2-ap)2, A] and [Mg(2-ab)2, C], the maximum antibacterial and antifungal activities were shown by the compound A. Among the ligands, 2-aminophenol (B) showed more antibacterial activity than 2-aminobenzoic acid (D). The minimum inhibitory concentration for the complex A against five pathogenic bacteria Streptococcus-haemolyticus, Bacillus subtilis, Staphylococcus aureus, Salmonella typhi and Escherichia coli were found in the range of 32-64 μg ml-1. The complexes were also tested for their cytotoxicity using brine shrimp lethality bioassay method and the LC50 values of the complexes A and C were found to be 5.7 and 24.3 µg ml-1 respectively. Antibacterial, antifungal and cytotoxic studies undertaken for the above compounds indicated structure-activity relationships. These metalloderivatives were more active than the parent compounds (ligands).
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