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Articles by M. A. Gafur
Total Records ( 5 ) for M. A. Gafur
  Golam Sadik , M. A. Gafur , M. Shah Alam Bhuiyan , A. H. M. Khurshid Alam , M. Helal U. Biswas , Parvez Hassan , Abdul Mannan , M. Omar Faruk Khan and A. K. A. Chowdhury
  The ethanolic extract of Pergularia daemia and its steroidal fraction were studied for antifertility activity. Both the ethanol extract and the steroidal fraction showed significant antifertility activity in the pre-implantation stage in female mice. The ethanol extract also showed late abortifacient activity
  Md. Golam Sadik , M. A. Gafur , M. Shah Alam Bhuiyan , M. Motiur Rahman and Helal U. Biswas
  The ethanol extract of Pergularia daemia and its steroidal fraction are reported to have antifertility activity. In this work we studied the alkaloidal fraction of the ethanol extract to observe its antifertility activity. Oral administration of the alkaloidal fraction at a dose of 200mg kg‾1 body weight showed a significant activity in preimplantation stage of female mice. The activity of the alkaloidal fraction, when compared with the steroidal fraction, was found to be more pronounced since the former inhibited not only the fertility of the female mice but also took short period to return the oestrous cycle to normal, with in 4 to 6 days of drug treatment while steroidal fraction treated mice returned to normal within 6 to 8 days.
  A. S. M. Anisuzzaman , Naoki Sugimoto , M. S. A. Bhuiyan , Golam Sadik and M. A. Gafur
  The chloroform extract and the two novel compounds streptmysone-A (I) and streptomysone-B (II) of the Czapek-Dox (alkaline) culture filtrate of the Streptomyces species were studied for cytotoxic and acute toxicity activities. The cytotoxic activity of the compounds and the extract was determined by brine shrimp lethality bioassay while the acute toxicity study was performed on Swiss albino mice. The LC50 values of chloroform extract(CHCl3), compound (I) and (II), and standard ampicillin trihydrate were found to be 3.89, 6.31, 125.8 and 6.31Fg ml-1, respectively. The LD50 values were found to be 66.34 and 79.49mg kg-1 for the compound (1) and (II), respectively.
  Zakia Sultana Sathi , A. S. M. Anisuzzaman , Golam Sadik and M. A. Gafur
  The subacute toxicity study of an antimicrobial compound, 4-hydroxy nitrobenzene isolated from a Streptomyces species was carried out on long Evan’s rats. The compound, 4-hydroxy nitrobenzene (300μg) was administered daily for 14 days and its effect on body weight, hematological and biochemical parameters of blood was investigated. There was no significant difference between weight gain in rats, receiving compound and control (121±5.10 vs 115±7.2g, respectively). There were no significant changes detected in hematology (red blood cells, 5.63±0.23 vs 4.97±0.17; white blood cells, 12575±170.78 vs 10950±238; platelet, 312500 ± 9574 vs 31000±21602 (cells ml-1)x106; hemoglobin, 13.25±0.3 vs 13.27 ±0.36%, for experimental and control rats, respectively) or blood biochemistry (serum glutamic oxaloacetic transaminase, 11.5±1.29 vs 11.75±1.25IU L-1, serum glutamate pyruvate transaminase, 8.25±1.26 vs 7.25±1.5IU L-1, serum alkaline phosphatase 41.25 ±1.89 vs 44.25 ± 3.3IU L-1. Uric acid, 7.05±0.129 vs 7.3± 0.22; urea, 42.25 ± 1.708 vs 41.5 ± 2.64; creatinine, 0.85±0.05 vs 1.07±0.188mg dL-1, for experimental and control rats, respectively). Therefore, the compound, 4-hydroxy nitrobenzene (300μg day-1) over 14 days, had no toxic effects on rats.
  A. S. M. Anisuzzaman , Naoki Sugimoto , S. A. Bhuiyan , Golam Sadik and M. A. Gafur
  The objective of this investigation is to determine the in vitro antimicrobial activity of the two novel compounds from Streptomyces. This antagonistic micro-organism was isolated and identified on the basis of morphological and biochemical study from the soil of the Northern district of Pabna, Bangladesh. The organism yielded maximum antimicrobial principle when grown at Czapek-Dox broth medium of pH 8 for 8 days at temperature 37.5C having rhamnose as carbon source. The antimicrobial principles were extracted from the fermentation broth by choloroform. The extract on chromatographic resolution yielded two antimicrobial compounds: Streptomysone-A (I) and Streptomysone-B (II). Both the compounds were screened for antimicrobial activity against eighteen pathogenic organisms which showed moderate to strong antimicrobial activity. The minimum inhibitory concentration (MIC) of the compounds against five pathogenic organisms were found to be between 32 to 128μg ml‾1.
 
 
 
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