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Articles by M Yano
Total Records ( 2 ) for M Yano
  A Komaru , N Kamiya , H Suzuki , T Endo , M Takano , M Yano , K Kawamura , T Imamoto and T. Ichikawa
  Objective

To determine the association between obesity and prostate cancer in Japanese recurrence after primary treatment with radical prostatectomy.

Methods

The subjects were 173 Japanese patients with prostate cancer who had been treated with radical prostatectomy at Chiba University Hospital between April 1997 and March 2007. Clinicopathological characteristics and biochemical recurrence outcomes after radical prostatectomy were compared between the three body mass index cohorts.

Results

Mean body mass index was 23.4 kg/m2 with a standard deviation of 2.4, and mean follow-up period was 37.4 months. Operative time was longer and estimated blood loss was much more in obese patients. Patients with pT3≥ had significantly higher serum prostate-specific antigen, total cholesterol levels, Gleason's sum and positive of surgical margin than pT2 patients. Recurrence rate was significantly higher in the 26.5 kg/m2 and hyperlipidemia groups in pT3≥ patients.

Conclusions

Obesity is an independent predictor of disease recurrence in Japanese patients with pT3≥ prostate cancer who underwent radical prostatectomy. Obese patients who underwent radical prostatectomy require vigilant follow-up care.

  Y Nishikawa , F Hirota , M Yano , H Kitajima , J. i Miyazaki , H Kawamoto , Y Mouri and M. Matsumoto
 

The roles of autoimmune regulator (Aire)–expressing medullary thymic epithelial cells (mTECs) in the organization of the thymic microenvironment for establishing self-tolerance are enigmatic. We sought to monitor the production and maintenance of Aire-expressing mTECs by a fate-mapping strategy in which bacterial artificial chromosome transgenic (Tg) mice expressing Cre recombinase under the control of the Aire regulatory element were crossed with a GFP reporter strain. We found that, in addition to its well recognized expression within mature mTECs, Aire was expressed in the early embryo before emergence of the three germ cell layers. This observation may help to explain the development of ectodermal dystrophy often seen in patients with AIRE deficiency. With the use of one Tg line in which Cre recombinase expression was confined to mTECs, we found that Aire+CD80high mTECs further progressed to an AireCD80intermediate stage, suggesting that Aire expression is not constitutive from after its induction until cell death but instead is down-regulated at the beginning of terminal differentiation. We also demonstrated that many mTECs of Aire-expressing lineage are in close contact with thymic dendritic cells. This close proximity may contribute to transfer of tissue-restricted self-antigens expressed by mTECs to professional antigen-presenting cells.

 
 
 
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