Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Articles by M Tighe
Total Records ( 1 ) for M Tighe
  R. S Misra , G Shi , M. E Moreno Garcia , A Thankappan , M Tighe , B Mousseau , K Kusser , S Becker Herman , K. L Hudkins , R Dunn , M. R Kehry , T. S Migone , A Marshak Rothstein , M Simon , T. D Randall , C. E Alpers , D Liggitt , D. J Rawlings and F. E. Lund

Survival of mature B cells is regulated by B cell receptor and BAFFR-dependent signals. We show that B cells from mice lacking the Gq subunit of trimeric G proteins (Gnaq–/– mice) have an intrinsic survival advantage over normal B cells, even in the absence of BAFF. Gnaq–/– B cells develop normally in the bone marrow but inappropriately survive peripheral tolerance checkpoints, leading to the accumulation of transitional, marginal zone, and follicular B cells, many of which are autoreactive. Gnaq–/– chimeric mice rapidly develop arthritis as well as other manifestations of systemic autoimmune disease. Importantly, we demonstrate that the development of the autoreactive B cell compartment is the result of an intrinsic defect in Gnaq–/– B cells, resulting in the aberrant activation of the prosurvival factor Akt. Together, these data show for the first time that signaling through trimeric G proteins is critically important for maintaining control of peripheral B cell tolerance induction and repressing autoimmunity.

Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility