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Articles by M Sugita
Total Records ( 1 ) for M Sugita
  Y Tani , T Funatsu , H Ashida , M Ito , S Itonori , M Sugita and K. Yamamoto
 

Hirsutella rhossiliensis, a nematophagous fungus belonging to the Ascomycota, is resistant to aureobasidin A (AbA). In this fungus, the biosynthetic pathway leading to mannosylinositolphosphoceramides, which is inhibited by AbA, was not detected. Instead, this fungus contains neutral complex glycosphingolipids (GSLs) and monoglycosylceramides. Except for monoglycosylceramides, neutral GSLs share a neogala-series core structure, Galβ1–6Galβ1-Cer. Among the GSLs of H. rhossiliensis, three novel GSLs with terminal Man and Glc residues on the sugar chain were elucidated. We analyzed GSL structure using compositional sugar, fatty acid, and sphingoid analyses, methylation analysis, matrix-assisted laser desorption ionization time-of-flight/mass spectrometry (MALDI-TOF MS), and 1H nuclear magnetic resonance spectroscopy (NMR). The following structures were determined: Man1–3Galβ1–6Galβ1–6Galβ1-Cer; Glc1–2Galβ1–6Galβ1–6Galβ1-Cer; and Man1–3Galβ1–6(Glc1–4)Galβ1–6Galβ1-Cer. In the ceramides, the fatty acids were predominantly saturated h24:0-acids and the sphingoids were predominately t18:0- or t18:1-sphingoids. In contrast, the ceramides of Glcβ1-Cer contained d18:2- and d19:2-sphingoids. These findings indicate the presence of a novel biosynthetic pathway of neogala-series GSLs in fungi.

 
 
 
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