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Articles by M Soares
Total Records ( 2 ) for M Soares
  E Rocha , M Soares , C Valente , L Nogueira , H Bonomo , M Godinho , M Ismael , R. V. R Valenca , J. E. S Machado and E. Maccariello
 

Background. This study aimed to evaluate and compare the characteristics and outcomes of patients with end-stage renal disease (ESRD) with those of matched controls of patients with acute kidney injury (AKI) requiring renal replacement therapy.

Methods. A case-control study was performed at the intensive care units (ICU) of three tertiary-care hospitals between December 2004 and September 2007. Patients were admitted with life-threatening complications and were matched for age and for severity of illness and organ dysfunctions. Conditional logistic regression was used to identify factors associated with hospital mortality.

Results. A total of 54 patients with ESRD and 54 patients with AKI were eligible for the study and were well matched. In general, clinical characteristics were similar. Nonetheless, comorbidities were more frequent in patients with ESRD, and patients with AKI more frequently required mechanical ventilation. ICU (43% versus 20%, P = 0.023) and hospital (50% versus 24%, P = 0.010) mortality rates were higher in patients with AKI. In addition, patients with AKI experienced longer ICU and hospitals stays. The SAPS II score had a regular ability in discriminating survivors and non-survivors, and tended to underestimate mortality in patients with AKI and overestimate in patients with ESRD. When all patients were evaluated, older age [OR = 1.05 (95% CI, 1.01–1.09)], poor chronic health status [OR = 3.90(1.19–12.82)] and number of associated organ failures [OR = 4.44(1.97–10.00)] were the main independent predictors of mortality. After adjusting for those covariates, ESRD was still associated with a lower probability of death [OR = 0.17 (0.06–0.050)].

Conclusions. ESRD patients with life-threatening complications had significantly better outcome than AKI patients.

  M. A Moody , H. X Liao , S. M Alam , R. M Scearce , M. K Plonk , D. M Kozink , M. S Drinker , R Zhang , S. M Xia , L. L Sutherland , G. D Tomaras , I. P Giles , J. C Kappes , C Ochsenbauer Jambor , T. G Edmonds , M Soares , G Barbero , D. N Forthal , G Landucci , C Chang , S. W King , A Kavlie , T. N Denny , K. K Hwang , P. P Chen , P. E Thorpe , D. C Montefiori and B. F. Haynes
 

Traditional antibody-mediated neutralization of HIV-1 infection is thought to result from the binding of antibodies to virions, thus preventing virus entry. However, antibodies that broadly neutralize HIV-1 are rare and are not induced by current vaccines. We report that four human anti-phospholipid monoclonal antibodies (mAbs) (PGN632, P1, IS4, and CL1) inhibit HIV-1 CCR5-tropic (R5) primary isolate infection of peripheral blood mononuclear cells (PBMCs) with 80% inhibitory concentrations of <0.02 to ~10 µg/ml. Anti-phospholipid mAbs inhibited PBMC HIV-1 infection in vitro by mechanisms involving binding to monocytes and triggering the release of MIP-1 and MIP-1β. The release of these β-chemokines explains both the specificity for R5 HIV-1 and the activity of these mAbs in PBMC cultures containing both primary lymphocytes and monocytes.

 
 
 
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