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Articles by M Cooper
Total Records ( 3 ) for M Cooper
  N. R Rigual , K Thankappan , M Cooper , M. A Sullivan , T Dougherty , S. R Popat , T. R Loree , M. A Biel and B. Henderson
 

Objective  To determine the response of dysplasia, carcinoma in situ (CIS), and T1 carcinoma of the oral cavity and larynx to photodynamic therapy with porfimer sodium.

Design  Prospective trial.

Setting  A National Cancer Institute–designated cancer institute.

Patients  Patients with primary or recurrent moderate to severe oral or laryngeal dysplasia, CIS, or T1N0 carcinoma.

Intervention  Porfimer sodium, 2 mg/kg of body weight, was injected intravenously 48 hours before treatment. Light at 630 nm for photosensitizer activation was delivered from an argon laser or diode laser using lens or cylindrical diffuser fibers. The light dose was 50 J/cm2 for dysplasia and CIS and 75 J/cm2 for carcinoma.

Main Outcome Measures  Response was evaluated at 1 week and at 1 month and then at 3-month intervals thereafter. Response options were complete (CR), partial (PR), and no (NR) response. Posttreatment biopsies were performed in all patients with persistent and recurrent visible lesions.

Results  Thirty patients were enrolled, and 26 were evaluable. Mean follow-up was 15 months (range, 7-52 months). Twenty-four patients had a CR, 1 had a PR, and 1 had NR. Three patients with oral dysplasia with an initial CR experienced recurrence in the treatment field. All the patients with NR, a PR, or recurrence after an initial CR underwent salvage treatment. Temporary morbidities included edema, pain, hoarseness, and skin phototoxicity.

Conclusion  Photodynamic therapy with porfimer sodium is an effective treatment alternative, with no permanent sequelae, for oral and laryngeal dysplasia and early carcinoma.

Trial Registration  clinicaltrials.gov Identifier: NCT00530088

  D. J Costa , T Sanford , C Janney , M Cooper and R. Sindwani
 

Objective  To analyze the radiographic, anatomic, and histologic characteristics of the nasal septal swell body.

Design  Computer-aided analysis of magnetic resonance images (MRIs) and histologic examination of cadaveric nasal septa.

Setting  Tertiary medical center.

Patients  Fifty-four head MRI studies were performed on adult live patients; we also used 10 cadaveric nasal septa.

Main Outcome Measures  Radiographic dimensions of the swell body and distances to other nasal landmarks were measured. Nasal septa and swell body histologic characteristics were evaluated using light microscopy. Relative proportions of vascular, connective, and glandular tissues within the swell body and the adjacent septum were compared.

Results  The swell body was fusiform shaped and located anterior to the middle turbinate, with mean (SD) width of 12.4 (1.9) mm; height, 19.6 (3.2) mm; and length, 28.4 (3.5) mm. The epicenter was 24.8 (2.9) mm from the nasal floor, 43.9 (4.1) mm from the nasal tip, and 39.0 (4.6) mm from the sphenoid face. Histologic analyses revealed that, compared with adjacent septal mucosa, the swell body contained significantly more venous sinusoids (37% vs 16%, P < .001) and fewer glandular elements (28% vs 41%, P < .001).

Conclusions  The swell body is a conserved region of the septum located anterior to the middle turbinate approximately 2.5 cm above the nasal floor. The high proportion of venous sinusoids within the swell body suggests the capacity to alter nasal airflow. Additional study is required before these findings are used in a clinical setting.

 
 
 
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