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Articles by Lin Yang
Total Records ( 4 ) for Lin Yang
  Xiao Yao , Hua Jiang , Cuizhen Zhang , Huamao Wang , Lin Yang , Yongfeng Yu , Junming Yu , Bizhi Shi , Zhijun Shen , Huiping Gao , Zhiwei Chen , Shujun Tian , Shun Lu , Zonghai Li and Jianren Gu
  Objective: We investigated whether or not there are autoantibodies for DKK1 (Dickkopf-1) in patients with non-small cell lung cancer (NSCLC) and whether this autoantibody can be used for cancer detection.
The levels of DKK1 autoantibodies were determined in 93 NSCLC patients and 87 healthy controls.
Results: We found that, in the sera, the presence of autoantibody against DKK1 was highly correlated with NSCLC. High anti-DKK1 autoantibody titres were found in the sera of NSCLC patients, whereas low or negative titres were found in the control group. The ROC curve results showed that autoantibody immunoassay exhibited 62% sensitivity and 84% specificity. The sensitivity for the detection of NSCLC in stage I also reach 64.3%. Furthermore, a combined ELISA assays for both DKK1 and autoantibody DKK1 increased sensitivity and classified 81.7% (76/93) of the NSCLC patients as positive, whereas only 13.8 % (12/87) of healthy volunteers were falsely diagnosed as positive.
Conclusions: Our results suggest that the detection of circulating DKK1 autoantibody could potentially serve as a useful non-invasive marker for determining lung cancer status.
  Jianhua Chen , Lin Yang , Dengtang Liu , Donghong Cui , Shunying Yu , Yan Li , Haisu Wu , Ying Yue , Yongyong Shi and Yifeng Xu
  The Metabolic Syndrome (MetS) could significantly increase the risk of morbidity and mortality from type II diabetes and cardiovascular disease. We carried out a systemical study to investigate the potential drug targets for effective treatment of clozapine-induced MetS. In our study, the differentially-expressed miRNAs (DERs) between schizophrenia patients with MetS and without MetS after the treatment of clozapine were identified. Target genes of these miRNAs were then retrieved from two miRNA databases (miRecods and miRTarBase) to identify the underlying mechanisms involved in the development of MetS. Interactors of the target genes were identified and a network was constructed using Osprey. Functional enrichment analysis was performed for all the genes in the network with DAVID (Database for Annotation, Visualization and Integrated Discovery). The results revealed that 3 DERs including Hsa-miR-330-3p (p = 0.00934), has-miR-18a (p = 0.001686) and has-miR-106b (p = 0.007531)were identified. In total, 4 target genes (E2F1, CTGF, ESR1 and ITCH) shared by both databases were picked out. What’s more, 8 significant pathways were revealed in the interaction network and the most significant pathway was positive regulation of macromolecule metabolic process (FDR = 1.80E-15). In conclusion, the 3 identified miRNAs might be the potential targets for treatment of MetS. And the results of our study provide ways to monitor the progression of MetS (e.g., serum levels of proteins), predict the outcome (e.g., polymorphisms) and even block the emergence of MetS.
  Meilin Wei , Ruiping Sun , Kai Jiang and Lin Yang
  Three porous coordination polymers, {[Nd(dpdo)2(H2O)5(CH3OH)2](PMo12O40)(CH3OH)-(H2O)5}n (1), {[Tb(dpdo)4(H2O)3](PMo12O40)(H2O)2CH3CN}n (2) and {[Tb(dpdo)4(H2O)3]H(SiMo12O40)(dpdo)0.5(CH3CN)0.5(H2O)4}n (3) (where dpdo is 4,4’-bipyridine-N,N’-dioxide), templated by single- or double-Keggin polyanions were synthesized and characterized by single crystal X-ray diffraction. The compounds exhibit three different 3D non-interwoven frameworks with large cavities occupied by the single- or double-Keggin-type anions. Thermogravimetric analyses suggest different stability for the three metal-organic frameworks. The SHG (second harmonic generation) efficiency of 1 confirms its noncentric framework.
  Lin Yang , Li Zhang , Qiuyu Wu and Douglas D. Boyd
  We previously described the novel zinc finger protein ZKSCAN3 as a new "driver" of colon cancer progression. To investigate the underlying mechanism and because the predicted structural features (tandem zinc fingers) are often present in transcription factors, we hypothesized that ZKSCAN3 regulates the expression of a gene(s) favoring tumor progression. We employed unbiased screening to identify a DNA binding motif and candidate downstream genes. Cyclic amplification and selection of targets using a random oligonucleotide library and ZKSCAN3 protein identified KRDGGG as the DNA recognition motif. In expression profiling, 204 genes were induced 2-29-fold, and 76 genes reduced 2-5-fold by ZKSCAN3. To enrich for direct targets, we eliminated genes under-represented (<3) for the ZKSCAN3 binding motif (identified by CAST-ing) in 2 kilobases of regulatory sequence. Up-regulated putative downstream targets included genes contributing to growth (c-Met-related tyrosine kinase (MST1R), MEK2; the guanine nucleotide exchanger RasGRP2, insulin-like growth factor-2, integrin β4), cell migration (MST1R), angiogenesis (vascular endothelial growth factor), and proteolysis (MMP26; cathepsin D; PRSS3 (protease serine 3)). We pursued integrin β4 (induced up to 6-fold) as a candidate target because it promotes breast cancer tumorigenicity and stimulates phosphatidyl 3-kinase implicated in colorectal cancer progression. ZKSCAN3 overexpression/silencing modulated integrin β4 expression, confirming the array analysis. Moreover, ZKSCAN3 bound to the integrin β4 promoter in vitro and in vivo, and the integrin β4-derived ZKSCAN3 motif fused upstream of a tk-Luc reporter conferred ZKSCAN3 sensitivity. Integrin β4 knockdown by short hairpin RNA countered ZKSCAN3-augmented anchorage-independent colony formation. We also demonstrate vascular endothelial growth factor as a direct ZKSCAN3 target. Thus, ZKSCAN3 regulates the expression of several genes favoring tumor progression including integrin β4.
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