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Articles by Lin Yan
Total Records ( 2 ) for Lin Yan
  Lin Yan , Jin Qiu , Jianbo Chen , Bridgett Ryan-Payseur , Dan Huang , Yunqi Wang , Lijun Rong , Jody A. Melton-Witt , Nancy E. Freitag and Zheng W. Chen
  While recombinant Listeria monocytogenes strains can be explored as vaccine candidates, it is important to develop attenuated but highly immunogenic L. monocytogenes vaccine vectors. Here, prfA* mutations selected on the basis of upregulated expression of L. monocytogenes PrfA-dependent genes and proteins were assessed to determine their abilities to augment expression of foreign immunogens in recombinant L. monocytogenes vectors and therefore enhance vaccine-elicited immune responses (a prfA* mutation is a mutation that results in constitutive overexpression of PrfA and PrfA-dependent virulence genes; the asterisk distinguishes the mutation from inactivation or stop mutations). A total of 63 recombinant L. monocytogenes vaccine vectors expressing seven individual viral or bacterial immunogens each in nine different L. monocytogenes strains carrying wild-type prfA or having prfA* mutations were constructed and investigated. Mutations selected on the basis of increased PrfA activation in recombinant L. monocytogenes prfA* vaccine vectors augmented expression of seven individual protein immunogens remarkably. Consistently, prime and boost vaccination studies with mice indicated that the prfA(G155S) mutation in recombinant L. monocytogenes ΔactA prfA* strains enhanced vaccine-elicited cellular immune responses. Surprisingly, the prfA(G155S) mutation was found to enhance vaccine-elicited humoral immune responses as well. The highly immunogenic recombinant L. monocytogenes ΔactA prfA* vaccine strains were as attenuated as the recombinant parent L. monocytogenes ΔactA vaccine vector. Thus, recombinant attenuated L. monocytogenes ΔactA prfA* vaccine vectors potentially are better antimicrobial and anticancer vaccines.
  Sun Jin , Lin Yan , Wang Xiao-Jing , Yang Zhen-Kui , Lin Rui-Hang and Gao Zhen-Zhong
  In this study, the middle density fiberboard and particle board were used to imitate the real living environment and discussed the effect of the different dose of formaldehyde emission of artificial board on physiological function of mice. The results show that there is no significant effect on the body weight of the mice. It also show that exposure to high-dose artificial board make the liver and ovary organ index reduced corresponding to the low-dose artificial board, but it has no any significant effect on the other organs. In addition, all of the experimental data of blood routine demonstrates that the formaldehyde emission of the artificial board has no significant differences about the physiological function of the mice. The reproductive organs sections of the mice indicate that exposure to the artificial board make a difference to the corpus luteum, seminiferous tubule and vas deferens.
 
 
 
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