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Articles by Lin Sun
Total Records ( 3 ) for Lin Sun
  Lin Sun , Jiucheng Xu , Chuan Wang , Tianhe Xu and Jinyu Ren
  This study, from the viewpoint of granularity, investigates the extended formulas and the formulation representation of granules and then introduces some operations of granules in rough sets. Within the framework of granular spaces presented, we examine their granular structure model. Moreover, some of their important propositions and properties are derived, the performances of which are shown through two illustrative examples. Furthermore, from the viewpoints of user interests and granular information processing, we develop a conceptual framework of knowledge retrieval based on the granular structure model which enlarges the application areas of granular computing.
  Qiong Huang , Jie Hu , Lin Sun and Qin Wang
  Heat Shock/Stress Proteins (HSPs) are a group of stress proteins which are closely associated with organisms’ adaptability to environment and the heat shock protein 70 is the most conserved and important member. Researchers cloned an hsp70 gene from Tenebrio molitor larvae by PCR and RACE Method and determined the mRNA abundance in the beetle developmental stages by real-time qPCR. The cDNA cloned was 2,282 bp in full length containing a 115 bp 5'untranslated region rich in adenine, a 1,935 bp open reading frame and a 232 bp 3'untranslated regionrich in adenine and thymine. It also had seven repeats of the Heat Shock Element (HSE) nGAAn in its 5'UTR and a 22 bp Poly (A) tail in the 3'UTR. The deduced heat shock protein had a highly conserved N-terminal ATPase domain and a conserved C-terminal peptide-binding domain. The tertiary structure of ATPase domain was made of two large globular subdomains which were separated by a deep cleft and the peptide-binding domain was a sandwich of 2 four-stranded β-sheets with four loops protruding upwards and two α-helices. Real-time qPCR analysis revealed that the hsp70 mRNA expression in T. molitor was characterized by heat-inducible and developmental-regulation features. The results form a basis for further research on structure, function and expression regulation of HSPs from T. molitor as well as to decipher the relationship between HSPs and stress-resistance in the beetle.
  Lin Sun , Shetha Shukair , Tejaswitha Jairaj Naik , Farzad Moazed and Hossein Ardehali
  Alterations in glucose metabolism have been demonstrated for diverse disorders ranging from heart disease to cancer. The first step in glucose metabolism is carried out by the hexokinase (HK) family of enzymes. HKI and II can bind to mitochondria through their N-terminal hydrophobic regions, and their overexpression in tissue culture protects against cell death. In order to determine the relative contributions of mitochondrial binding and glucose-phosphorylating activities of HKs to their overall protective effects, we expressed full-length HKI and HKII, their truncated proteins lacking the mitochondrial binding domains, and catalytically inactive proteins in tissue culture. The overexpression of full-length proteins resulted in protection against cell death, decreased levels of reactive oxygen species, and possibly inhibited mitochondrial permeability transition in response to H2O2. However, the truncated and mutant proteins exerted only partial effects. Similar results were obtained with primary neonatal rat cardiomyocytes. The HK proteins also resulted in an increase in the phosphorylation of voltage-dependent anion channel (VDAC) through a protein kinase Cε (PKCε)-dependent pathway. These results suggest that both glucose phosphorylation and mitochondrial binding contribute to the protective effects of HKI and HKII, possibly through VDAC phosphorylation by PKCε.
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