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Articles by Lin Liu
Total Records ( 3 ) for Lin Liu
  Liping Wan , Chun Wang , Lin Liu , Xiaoqiong Tang , Jinghua Wang , Yue Guan , Ming Jiang , Xianlin Duan , Xiaoyan Ke , Hongmei Jing , Jiong Hu , Ling Wang , Yuming Li and Li Geng
  Invasive Fungal Disease (IFD) is a major cause of death in severe neutropenic patients with hematologic malignancies. Micafungin, a new echinocandin antifungal drug, is effective in treating IFD. However, the efficacy and safety of micafungin in preventing IFD in severe neutropenic patients with hematologic malignancies have not been demonstrated. A prospective and multicenter clinical study was conducted to evaluate the efficacy and safety of micafungin as prophylaxis for IFD. Micafungin 50 mg daily was administered intravenously to 117 high-risk patients with hematologic malignancies undergoing intensive chemotherapy or Hematopoietic Stem Cell Transplantation (HSCT), for a median of 24 days. Successful prophylaxis (no proven, probable or possible IFD up to 1 week after the end of prophylactic treatment) was achieved in 88.54% patients. No patient developed proven IFD during treatment and only 2.08% had probable IFD and 9.38% possible IFD. Micafungin potentially accounted for adverse events in 6.84% of patients. No severe adverse events attributable to micafungin were seen. Micafungin 50 mg daily is a promising prophylactic antifungal therapy for neutropenic patients with hematologic malignancies.
  Feida Sun , Wenye Chen , Ye Qing , Lin Liu and Wei Liu
  Understanding the relationships between degrees of Plateau pika density and plants biomass is essential for improving the management of pika populations in alpine meadow ecosystems. Twelve survey sites with active burrow of plateau pika were classified into four degrees of density: approximately zero-density, low-density, medium-density and high-density to evaluate pika populations and biomass allocation interactions. The results revealed that plant composition, overall vegetation height and cover, dominant species were significantly different among the four sites. Additionally, plant functional groups, aboveground, belowground and total biomass, root:shoot ratios and the proportion of living roots were greatest at the zero-density site and those at the medium-density site were the lowest. Researchers postulate that pika activities may not be the source of the differences but a symptom of grassland degradation. As such, a reduction of livestock numbers, a variable rotational grazing system, restorative management techniques and community participation in co-management of the meadows are likely to effectively improve grassland productivity and deter pika outbreaks. Further, pika population fluctuations should be monitored and when the population exceeds the economic threshold of low-density (110 pikas or/and 512 active burrows ha-1) or reaches high-density (200 pikas or/and 1360 active burrows ha-1) integrated management strategies should be implemented to protect damage.
  Deming Gou , Amarjit Mishra , Tingting Weng , Lijing Su , Narendranath Reddy Chintagari , Zhixin Wang , Honghao Zhang , Li Gao , Pengcheng Wang , Heidi M. Stricker and Lin Liu
  Annexin A2, a calcium-dependent phospholipid-binding protein, is abundantly expressed in alveolar type II cells where it plays a role in lung surfactant secretion. Nevertheless, little is known about the details of its cellular pathways. To identify annexin A2-regulated or associated proteins, we silenced endogenous annexin A2 expression in rat alveolar type II cells by RNA interference and assessed the change of the cellular transcriptome by DNA microarray analysis. The loss of annexin A2 resulted in the change of 61 genes. Thirteen of the selected genes (11 down-regulated and 2 up-regulated genes) were validated by real time quantitative PCR. When the loss of rat annexin A2 was rescued by overexpressing EGFP-tagged human annexin A2, six of seven selected targets returned to their normal expression level, indicating that these genes are indeed annexin A2-associated targets. One of the targets, Rab14, co-immunoprecipitated with annexin A2. Rab14 also co-localized in part with annexin A2 and lamellar bodies in alveolar type II cells. The silencing of Rab14 resulted in a decrease in surfactant secretion, suggesting that Rab14 may play a role in surfactant secretion.
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