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Articles by Lijuan Wang
Total Records ( 3 ) for Lijuan Wang
  Yinghui Ling , Lijuan Wang , Xiaodong Zhang , Lina Xu , Jian-Ping Ding , Yun-Hai Zhang , Zijun Zhang and Xiao-Rong Zhang
  This study is about the correlation between COX II gene genetic variation and adult buck sperm motility traits, to provide genetics reference for the goat breeding. In this study, 120 adult male goat semen samples were collected from four populations. COX II gene polymorphism information was rapid screened using DNA pool and sequencing method. Each individual polymorphism of these goats was detected by RFLP. Sequencing results of DNA pool showed a single nucleotide mutation in COX II gene (A→G). The mutation caused a change of Hind III restriction site. RFLP results showed that the mutation associated with goat sperm traits. The vitality of fresh sperm and frozen sperm from BB-type goats was significantly higher than AA-type. This study provided foundation for establishment relationship between COX II gene SNP and goat sperm motility traits. It could be considered as a reference marker-assisted selection for buck semen quality traits and goat breeding.
  Yang Wang , Lijuan Wang , Tianwei Zhang and Qingdong Zhou
  Classification station plays an important role in railway transportation. It faced various possible schemes when marshaling station would be extended. Decision makers were concern to how to choose feasible extension scheme so as to minimize the total investment. Based on the actual development, optimization model of extension of classification station is built. The objective function is to minimize the total investment, subject to three groups: First is the sorting capacity is to meet the demand, second is the utilization of sorting capacity is not too low, the last is the capacity of feasible scheme should e is larger than former. In order to reduce the difficulty of solving model directly, this model is transformed into shortest path model. The specific solution is expounded through an example application. The use area of the model is described in the end. The model can be used in the macro-control by high-level leader. The specific micro-operation can be done in this decision.
  Dong Jiang , Haitao Guo , Chunxiao Xu , Jinhong Chang , Baohua Gu , Lijuan Wang , Timothy M. Block and Ju-Tao Guo
  Hepatitis C virus (HCV) infection is a common cause of chronic hepatitis and is currently treated with alpha interferon (IFN-α)-based therapies. However, the underlying mechanism of IFN-α therapy remains to be elucidated. To identify the cellular proteins that mediate the antiviral effects of IFN-α, we created a HEK293-based cell culture system to inducibly express individual interferon-stimulated genes (ISGs) and determined their antiviral effects against HCV. By screening 29 ISGs that are induced in Huh7 cells by IFN-α and/or up-regulated in HCV-infected livers, we discovered that viperin, ISG20, and double-stranded RNA-dependent protein kinase (PKR) noncytolytically inhibited the replication of HCV replicons. Mechanistically, inhibition of HCV replication by ISG20 and PKR depends on their 3`-5` exonuclease and protein kinase activities, respectively. Moreover, our work, for the first time, provides strong evidence suggesting that viperin is a putative radical S-adenosyl-L-methionine (SAM) enzyme. In addition to demonstrating that the antiviral activity of viperin depends on its radical SAM domain, which contains conserved motifs to coordinate [4Fe-4S] cluster and cofactor SAM and is essential for its enzymatic activity, mutagenesis studies also revealed that viperin requires an aromatic amino acid residue at its C terminus for proper antiviral function. Furthermore, although the N-terminal 70 amino acid residues of viperin are not absolutely required, deletion of this region significantly compromises its antiviral activity against HCV. Our findings suggest that viperin represents a novel antiviral pathway that works together with other antiviral proteins, such as ISG20 and PKR, to mediate the IFN response against HCV infection.
 
 
 
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