Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
 
Articles by Ligong Chen
Total Records ( 2 ) for Ligong Chen
  Shuo Xiang , Ligong Chen , Xin Yang , Peili Zhang and Liye Zhu
  Several triester derivatives with enhanced physicochemical and tribological properties were obtained from Waste Cooking Oil (WCO) through the following chemical modifications successively, transesterification of WCO, epoxidation of Fatty Acid Methyl Ester (FAME) and oxirane ring opening with anhydrides. Effect of the chain length increase of anhydrides on the low temperature fluid, viscometric properties and oxidation stability of triester derivatives were studied using pour point tester, viscometer and Pressurized Differential Scanning Calorimetry (PDSC), respectively. The tribological properties of triester derivatives were evaluated on a four-ball tribotester and the morphology of worn surfaces of steel balls was investigated by SEM. All triester derivatives showed better physicochemical properties, anti-wear ability and higher load-carrying capacity compared to 250BS, a representative of mineral oils. The three-step chemical modifications of the WCO re-utilization proposed in this study provide a feasible method to obtain high value-added and eco-friendly products, i.e., biolubricants.
  Anurag Purushothaman , Ligong Chen , Yang Yang and Ralph D. Sanderson
  High levels of heparanase are an indicator of poor prognosis in myeloma patients, and up-regulation of the enzyme enhances tumor growth, angiogenesis, and metastasis in animal models. At least part of the impact of heparanase in driving the aggressive tumor phenotype is due to its effect on increasing the expression and shedding of the heparan sulfate proteoglycan syndecan-1, a molecule known to promote myeloma progression. The present work demonstrated that elevation in heparanase expression in myeloma cells stimulates sustained ERK phosphorylation that in turn drives MMP-9 expression. In addition, urokinase-type plasminogen activator (uPA) and uPA receptor expression levels increased, and blocking the proteolytic activation of either MMP-9 or uPA inhibited the heparanase-induced increase in syndecan-1 shedding. Together these data provide a mechanism for heparanase-induced syndecan-1 shedding and, more importantly, demonstrate that heparanase activity in myeloma cells can lead to increased levels of proteases that are known to play important roles in the aggressive behavior of myeloma tumors. This in addition to its other known biological roles, indicates that heparanase acts as a master regulator of the aggressive tumor phenotype by up-regulating protease expression and activity within the tumor microenvironment.
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility