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| Articles
by
Liang Zhou |
Total Records (
2 ) for
Liang Zhou |
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Xiao-Hui Si
,
Yong-Fang Yao
,
Shuan-Ling Zhang
,
Wei Liu
,
Liang Zhou
and
Huai-Liang Xu
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The Duffy Antigen Receptor for Chemokines (DARC) gene
also called Duffy or FY, Plasmodium vivax and Plasmodium knowlesi
use DARC to trigger internalization into red blood cells and cause malaria,
the malaria life cycle in humans and nonhuman primates. In order to investigate
DARC gene in golden snub-nosed monkey (Rhinopithecus roxellanae),
two pairs of primers were designed based on DARC gene sequence of the
Macaca mulatta (HQ285849.1) and used to amplify approximately 1.0 and
1.1 kb DNA fragments respectively by PCR technique from genomic DNA sample of
golden monkey. The DNA, sequencing and combing results showed that the DARC
gene of the golden monkey was 1593 bp in length and contained a 47 bp 5 flanking
region, two extrons (21 and 990 bp), one complete intron (478 bp) and a 57 bp
3 flanking region. The Open Reading Fragment (ORF) was 1011 bp and encoded 336
amino acid residues. The DARC was a hydrophobic protein with less hydrophilic
components. The prediction of topological structure for the protein indicated
that it contained 16 potential function sites: three N-glycosylation sites,
one protein kinase C phosphorylation site, two casein kinase II phosphorylation
sites and ten N-myristoylation sites. In addition, the protein comprised seven
transmembrane helix regions and four extracellular regions and four intracellular
regions. Alignment analysis revealed that the homologies of DARC gene
nucleotide sequence of golden snub-nosed monkey with other primate species and
human was 95-99% and the homologies of amino acid sequence was 80-99%. These
results would provide the molecular basis for golden monkey against human malarias. |
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Yong-Hui Zhou
,
Liang Zhou
,
Hong-Yan Li
,
You-Xuan Zheng
,
Xiao-Zeng You
,
Hong-Jie Zhang
and
Jing Wu
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The photoluminescence properties of one europium complex Eu(TFNB)3Phen (TFNB = 4,4,4-trifluoro-1-(naphthyl)-1,3-butanedione, Phen = 1,10-phenanthroline) doped in a hole-transporting material CBP (4,4′-N,N′-dicarbazole-biphenyl) films were studied. A series of organic light-emitting devices (OLEDs) using Eu(TFNB)3Phen as the emitter were fabricated with a multilayer structure of indium tin oxide, 250Ω/square)/TPD (N,N′-diphenyl-N,N′-bis(3-methyllphenyl)-(1,1′-biphenyl)-4,4′-diamine, 50 nm)/Eu(TFNB)3phen (x): CBP (4,4′-N,N′-dicarbazole-biphenyl, 45 nm)/BCP (2,9-dimethyl-4,7-diphenyl-l,10 phenanthroline, 20 nm)/AlQ (tris(8-hydroxy-quinoline) aluminium, 30 nm)/LiF (1 nm)/Al (100 nm), where x is the weight percentage of Eu(TFNB)3phen doped in the CBP matrix (1-6%). A red emission at 612 nm with a half bandwidth of 3 nm, characteristic of Eu(III) ion, was observed with all devices. The device with a 3% dopant concentration shows the maximum luminance up to 1169 cd/m2 (18 V) and the device with a 5% dopant concentration exhibits a current efficiency of 4.46 cd/A and power efficiency of 2.03 lm/W. The mechanism of the electroluminescence was also discussed. |
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