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Articles by Li Shen
Total Records ( 4 ) for Li Shen
  Andrew J. Saykin , Li Shen , Tatiana M. Foroud , Steven G. Potkin , Shanker Swaminathan , Sungeun Kim , Shannon L. Risacher , Kwangsik Nho , Matthew J. Huentelman , David W. Craig , Paul M. Thompson , Jason L. Stein , Jason H. Moore , Lindsay A. Farrer , Robert C. Green , Lars Bertram , Clifford R. Jack Jr. and Michael W. Weiner
  The role of the Alzheimer’s Disease Neuroimaging Initiative Genetics Core is to facilitate the investigation of genetic influences on disease onset and trajectory as reflected in structural, functional, and molecular imaging changes; fluid biomarkers; and cognitive status. Major goals include (1) blood sample processing, genotyping, and dissemination, (2) genome-wide association studies (GWAS) of longitudinal phenotypic data, and (3) providing a central resource, point of contact and planning group for genetics within the Alzheimer’s Disease Neuroimaging Initiative. Genome-wide array data have been publicly released and updated, and several neuroimaging GWAS have recently been reported examining baseline magnetic resonance imaging measures as quantitative phenotypes. Other preliminary investigations include copy number variation in mild cognitive impairment and Alzheimer’s disease and GWAS of baseline cerebrospinal fluid biomarkers and longitudinal changes on magnetic resonance imaging. Blood collection for RNA studies is a new direction. Genetic studies of longitudinal phenotypes hold promise for elucidating disease mechanisms and risk, development of therapeutic strategies, and refining selection criteria for clinical trials.
  Kei Kawana , Junko Matsumoto , Shiho Miura , Li Shen , Yukiko Kawana , Takeshi Nagamatsu , Toshiharu Yasugi , Tomoyuki Fujii , Tomoyuki Fujii , Alison J. Quayle , Yuji Taketani and Danny J. Schust
  Mucosal epithelia of the human lower reproductive tract (vagina, cervix, and penile urethra) are exposed to sexually transmitted microbes, including Chlamydia trachomatis. The in vivo susceptibility of each tissue type to infection with C. trachomatis is quite distinct. CD1d is expressed on the surface of antigen-presenting cells, including mucosal epithelial cells, and interacts specifically with invariant NKT cells. Invariant NKT cells play a role in both innate and adaptive immune responses to microbes. Here we assessed CD1d expression in normal reproductive tissues by using immunohistochemistry. Immortalized epithelial cell lines from the human lower reproductive tract (vagina, endocervix, and penile urethra) were examined for CD1d expression and for ligand-induced cytokine production induced by CD1d cross-linking. CD1d expression in normal tissue was strong in the vagina but weak in the endocervix and penile urethra. Gamma interferon exposure induced CD1d transcription in all of the cell types studied, with the strongest induction in vaginal cells. Flow cytometry revealed cell surface expression of CD1d in vaginal and penile urethral epithelial cells but not in endocervical cells. Ligation of surface-expressed CD1d by monoclonal antibody cross-linking promoted interleukin-12 (IL-12) and IL-15, but not IL-10, production in vaginal and penile urethral cells. No induction was demonstrated in endocervical cells. CD1d-mediated cytokine production in penile urethral cells was abrogated by C. trachomatis infection. Basal deficiency in CD1d-mediated immune responsiveness may result in susceptibility to sexually transmitted agents. Decreased CD1d-mediated signaling may help C. trachomatis evade detection by innate immune cells.
  Xinbiao Gan , Gang Han , Li Shen and Zhiying Wang
  In order to leverage discrepancy of Sensor for attributes fusion in Heterogeneous Sensor System, Weighted Sensor attributes Fusion Based on OWA (Ordered Weighted Averaging) operators is proposed, in which attributes collecting from various sensors would be transformed according to sensor Weights and then attribute Fusion should be performed with normalized attributes, which would improve performance for attribute Fusion in Heterogeneous Sensor System and guide decision making in target recognition. Furthermore, an illustrative case study is given to validate our proposed techniques.
  Sheng-Jun Dai , Li Shen and Yan Ren
  Two new eudesmane-type sesquiterpenoids, lyratol A-B (1 and 2), were isolated from the whole plant of Olanum lyratum Thunb and their structures were elucidated by extensive spectroscopic analyses. In addition, two new compounds were found to show significant cytotoxicity against selected cancer cells in vitro, including P-388 and HT-29.
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