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Articles by Li Deng
Total Records ( 3 ) for Li Deng
  Bin Zhuge , Li Deng , Huanhuan Song , Guowei Dai , Weiming Wang and Julong Lan
  With the increasing number and variety of network business, the existing Internet architecture can’t be able to meet the ubiquitous, heterogeneous and credible requirements of advanced services at home and abroad. Many new institutions and individuals have begun to research the next generation of network’s architecture which is called reconfigurable network. Reconfigurable network can be divided into Atomic Capability layer and Atomic Service layer and Business layer. In order to achieve effective cooperation between the upper and lower layers in the hierarchical model, this study plans to design a "mapping" mechanism to complete the virtual network requests between upper and lower layers. This study proposes a virtual link embedding and virtual node embedding algorithm to complete the service request process. Simulation result shows that: the algorithm plays an important role in improving the utilization of network resources as well as energy saving.
  Hong-Ming Zhu and Li Deng
  Context: Traditional Herbal Medicine (THM) has many advantages that make it a promising choice for the treatment of ischemic heart disease (IHD). To study the mechanism of IHDs or pharmacological actions of THM, many hypoxia-induced cardiomyocyte injury models have been established. Radix Salvia miltorrhiza (Danshen) was used as a representative of THM. Danshen is a famous medicinal herb widely applied in Asia to relieve ischemic cardiovascular diseases. Objective: To investigate the effects of various hypoxic conditions and discuss a suitable hypoxia model, cell viability, apoptosis, release of myocardial injury markers, and mRNA levels of target genes were tested for the first time. Materials and methods: Radix Salvia miltorrhiza (Danshen) was purchased from a GMP-compliant producer and both its preparation method and quality control were standardized. Cellular status, such as cell viability, apoptosis, releases of myocardial injury markers, and the mRNA level of target gene were tested by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) method, biochemical analyzer, flow cytometry, Hoechst 33258 staining, and real-time PCR, respectively. Results: Based on our data, we found a treppe response of cardiomyocyte in the hypoxic condition and suggested that 8 h in 2% O2 might be a suitable condition for in vitro pharmacological study of cardiomyocytes. Discussion and conclusions: Our findings outlined more extended and in-depth capability of cardiomyocyte suffering from hypoxia, and might be of particular interest due to the high prevalence of THM pharmacological study.
  Hui Xiao , Wen Qian , Kirk Staschke , Youcun Qian , Grace Cui , Li Deng , Mariam Ehsani , Xiliang Wang , Yue-Wei Qian , Zhijian J. Chen , Raymond Gilmour , Zhengfan Jiang and Xiaoxia Li
  IL-1 receptor-associated kinase (IRAK) is phosphorylated, ubiquitinated, and degraded upon interleukin-1 (IL-1) stimulation. In this study, we showed that IRAK can be ubiquitinated through both Lys-48- and Lys-63-linked polyubiquitin chains upon IL-1 induction. Pellino 3b is the RING-like motif ubiquitin protein ligase that promotes the Lys-63-linked polyubiquitination on IRAK. Pellino 3b-mediated Lys-63-linked IRAK polyubiquitination competed with Lys-48-linked IRAK polyubiquitination for the same ubiquitination site, Lys-134 of IRAK, thereby blocking IL-1-induced IRAK degradation. Importantly, the negative impact of Pellino 3b on IL-1-induced IRAK degradation correlated with the inhibitory effect of Pellino 3b on the IL-1-induced TAK1-dependent pathway, suggesting that a positive role of IRAK degradation in IL-1 induced TAK1 activation. Taken together, our results suggest that Pellino 3b acts as a negative regulator for IL-1 signaling by regulating IRAK degradation through its ubiquitin protein ligase activity.
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