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Articles by Levina Ferdiana Adiwibowo
Total Records ( 1 ) for Levina Ferdiana Adiwibowo
  Elin Yulinah Sukandar , Joseph Iskendiarso Sigit and Levina Ferdiana Adiwibowo
  Earlier studies from our laboratory have indicated renal function improving action of corn silk and binahong in gentamicin-piroxicam induced kidney failure. This study was aimed to determine the effects of combination of cornsilk and binahong extracts on kidney failure model in rat and the effects of the extract combination on oxidative stress. Rats were divided into the positive control group, the group treated with 75 mg kg-1 of corn silk, the group treated with 100 mg kg-1 b.wt. of binahong, two groups treated with graded doses of combination of corn silk and binahong and the negative control group. Serum creatinine, urea, organ-to-body weight ratio of the kidney (kidney index) and renal histology were assessed to determine renal function. Meanwhile, the activities of lipid peroxidation, catalase and Superoxide Dismutase (SOD) were measured to analyse oxidative stress level. Administration of combination of the extracts at half dose resulted in marked depletion of serum creatinine and urea which was comparable to the results in corn silk-and binahong-treated groups. In addition, the extract combination was shown to reduce kidney index compared to that of the positive control group. The combination was further revealed to reduce renal damage histologically. Administration of the extract combination was demonstrated to attenuate kidney oxidative stress as shown by the reduction in lipid peroxidation and the increased activity of antioxidant enzymes, such as catalase and SOD. Taken together, results of this study suggest that corn silk in combination with binahong possesses renal function improving activity which is slightly better compared to the activity of each extract alone. The results further indicate that reduction of oxidative stress by each extract as well as their combination might be beneficial to the repair of renal damage.
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