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Articles by Leilei Wang
Total Records ( 2 ) for Leilei Wang
  Kefeng Xiao , Zhihui Hao , Dedong Hu and Leilei Wang
  Solution Enhanced Dispersion by Supercritical fluid (SEDS) process is utilized more and more widely for preparing nano-drug. Nozzle is the key component in SEDS process. In this study, the flow in jet-swirl nozzle for preparing nano-drug in SEDS process was analyzed by Computational Fluid Dynamics (CFD). It can be concluded from the results that the jet mixing length was found to be a strong function of the volume flow of supercritical CO2 (SC-CO2) at the inlet of the swirl chamber. When the volume flow of SC-CO2 was equal to or greater than 25 mL min-1, methylene chloride and SC-CO2 mixed completely in the nozzle. These results were coincident with the results obtained from experiments in literature. In additional, it also was indicated that the turbulent intensity at the outlet was all even in different volume flow of SC-CO2 and with the increase of volume flow of SC-CO2, the turbulent intensities at the outlet become greater and greater. These results were similar with the results obtained from experiments in literature. By these CFD analysis and comparison with literature, the flow parameters in jet-swirl nozzle were revealed and the method of CFD analysis for SEDS process was validated.
  Kefeng Xiao , Zhihui Hao and Leilei Wang
  The comparison on the performance between tangential-inlet swirl nozzle and coaxial nozzle was conducted by Computational Fluid Dynamics (CFD) simulation. The two nozzles were special for the preparation of nano-drug in Solution enhanced dispersion by supercritical fluid (SEDS) process. Turbulent intensity, velocity magnitude and volume fraction of ethanol were selected to act as the parameters to be compared. The results of CFD simulation indicate that, on the one hand, both coaxial nozzle and tangential-inlet swirl nozzle can meet the requirement of preparing nano-drug in SEDS process and have their advantages. Coaxial nozzle can prepare particles with more even size distribution than tangential-inlet swirl nozzle. And tangential-inlet swirl nozzle, with more merits, can produce higher turbulence intensity on the boundary layer which prevents the crystal nuclei precipitated from adhering on the inner wall. In additional, tangential-inlet swirl nozzle can produce higher velocity at outlet which can decrease the growth time of crystal nuclei so as to prepare superfine particles. On the other hand, both of the nozzles have their relative defects which should be improved in future study.
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