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Articles by Lawrence U.S. Ezeanyika
Total Records ( 4 ) for Lawrence U.S. Ezeanyika
  Cemaluk C. Egbuonu Anthony , Ambrose E. Ogbu and Lawrence U.S. Ezeanyika
  The study assessed the effect on some serum functions and organ histology following esculetin exposure in rats. Five groups (n = 6) of Wistar rats respectively received (A) 6.0 mg kg-1 body weight (b.wt.), (B) 12.0 mg kg-1 b.wt. (C) 24.0 mg kg-1 b.wt. of esculetin, (D, vehicle control) 0.2 mL kg-1 b.wt. of 10% dimethylsulfoxide, DMSO and (E, normal control) 0.2 mL kg-1 b.wt. of Distilled Water (DW) per orally and daily for 28 days. On comparison with the controls, a dose dependent and significant (p<0.05) decrease in the concentration of serum sodium ion (141.00±5.02 mmol L-1) but an increase in that of potassium ion (9.39±3.24 mmol L-1) was observed in the group C rats. The decrease in the serum protein concentration (6.58±0.77 mmol L-1) in the group C rats, though dose dependent, was not significant (p>0.05). In the group C rats, the decrease (p<0.05) in the serum urea concentration (10.95±0.61 mmol L-1) was dose dependent but the increase (p<0.05) in the serum creatinine concentration (85.87±8.31 mmol L-1) was not dose dependent. Histological examination revealed a severely dilated hepatic vein (A) and proliferated cells around the bile canaliculi (B) in group C rats. Other organs examined (kidney, testis, brain and heart) did not show any lesion in the test groups. The results showed that the esculetin-induced improvement in the serum parameters might not alter the studied organ histology in the rats, especially at the lower tested concentrations.
  Anthony C.C. Egbuonu , Ifeoma I. Ijeh , Onyinye N.C. Egbuonu , Lawrence U.S. Ezeanyika and Onyechi O. Obidoa
  A reduction in the concentration of nitric oxide, a biosynthetic product of L-arginine (ARG) was associated with the pathophysiology of Metabolic Syndrome (MES). This study assessed the effect of ARG on some anthropometric parameters of MES in normal rats. Female wistar rats (60-80 g) were randomized into two groups (n = 8 animals) and exposed to 60 mg kg-1 (b.wt.) of ARG and 3 mL kg-1 b.wt. of distilled water respectively as treated and control groups. Twenty eight days oral exposure to ARG caused a significant (p<0.01) increase in feed efficiency (4.83±0.06 or 19.26 %) and total water consumption (0.83±0.17 L or 25.75%), but a significant (p<0.01) decrease in total feed intake (0.31±0.06 kg or 20.51%), indicating suppressed calorie storage or decreased energy balance that may improve MES. Changes observed in the rats final length (0.30±0.01 m or 3.45%), total body weight gain (0.05±0.01 kg or 16.66%), body mass index (1.24±0.15 kg m-2 or 1.59%) and lean body weight (0.27±0.03 kg or 0.73%) though insightful, were not significant (p>0.05), warranting follow up. From the results of Pearson correlations analysis, feed efficiency correlated negatively with total feed intake (p = 0.01) but positively (p = 0.05) with total water consumption, suggesting apparent synergy in the ARG-induced effects. Thus, ARG significantly improved some anthropometric parameters of MES, hence may improve some MES features related to excessive calorie build up or storage in the female rats. The findings warrant similar studies on a longer duration for meticulousness.
  Anthony C.C. Egbuonu , Ifeoma I. Ijeh , Lawrence U.S. Ezeanyika and Onyechi O. Obidoa
  High blood pressure (a condition associated with vascular constriction) is a major feature of metabolic syndrome (MES). MES, a constellation of metabolic disorders, is prevalently higher in females and was associated with a reduced concentration of a vasodilator molecule, Nitric Oxide (NO). L-arginine (ARG), a precursor of NO may improve MES, warranting this study. Two groups (n = 8) of female Wistar albino rats were (per orally for twenty eight days) exposed to a single dose of 60 mg kg-1 b.wt. of ARG and 3 mL kg-1 b.wt. of distilled water, DW, respectively as treated and control groups. Significant differences in means were separated by student’s t-test (p<0.05; p<0.01) and results expressed as Mean±Standard deviation. ARG exposure caused a significant reduction (p<0.01) in sodium ion (Na+) concentration (136.42±1.66 mmol L-1; 6.54%), but a non-significant decrease (p>0.05) in potassium ion (K+) concentration (4.54±0.66 mmol L-1; 14.01%) in the rats’ serum, suggesting improved/reduced blood pressure. ARG treatment in the rats had a significant increase (p<0.01) in Alkaline Phosphatase (ALP) activity (8.30±0.23 IU L-1; 196.43%) in the rats’ serum, indicating adverse influence on high metabolic organs, including the brain. Sodium ion had a significant negative correlation (r = 0.01) with potassium ion, whereas the heart histomorphology revealed degenerations in the ARG-fed rats, apparently confirming the observations and suggestions thereto. Thus, ARG may improve blood pressure in the rats, perhaps at the expense of compromised heart function and histology of the rats. These may be pointing to a new arginine phenomenon, hence warrant follow up.
  Anthony Cemaluk C. Egbuonu , Daniel C. Nkwazema and Lawrence U.S. Ezeanyika
  The health concerns about working in a petroleum depot without wearing a Personal Protective Equipment (PPE) warranted this study. The anthropometric, lipid profile and blood pressure status were assessed by standard methods in asymptomatic adult male depot workers (n = 64) and male university students (n = 64), in Calabar metropolis, Nigeria. The concentration (mmol L-1) of total cholesterol (5.21±0.90), triacylglycerol (1.23±0.20) and very low density lipoprotein (0.56±0.19) respectively in the serum of the depot workers were significantly (p<0.05) higher than in the control (5.09±0.04, 1.15±0.04 and 0.52±0.09). The body weight (73.75±0.11 kg), height (1.72±0.1 m) and body mass index, BMI, (24.58±0.73 kg m‾2) of the depot workers were higher (p>0.05) than that of the control. The Blood Pressure (BP) of the exposed group (120/90±1.38 mmHg) and the control (120/80±1.14 mmHg) differed only in the Diastolic Blood Pressure (DBP) by 10 mmHg and in the calculated systolic to diastolic blood pressure ratio (SBP:DBP) by 0.17. The study suggested cardiovascular risks and impaired lipid metabolism in the petroleum depot workers. The health implications of this study warrant a follow up perhaps, in a larger population and sample size. The study underscored the need for the petroleum depot workers to wear personal protective equipment and to assess their health status on a regular basis.
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