Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the
coverage of the most important and influential journals
to meet the needs of the global scientific community.
Anti-nociceptive and anti-inflammatory effects of methanolic extract of Wrightia arborea (MEWA) were examined using different models in rats. MEWA was given to rats orally upto 2000 mg kg-1 b.wt. for acute toxicity study and observed for 14 days. Anti-nociceptive activity was evaluated in rats against Acetic acid induced writhing (chemically induced pain) and Tail immersion method (thermally induced pain). Acute anti-inflammatory activity of MEWA was also evaluated in Formaline-induced rat paw edema model and Carrageenan-induced hind paw edema model in rats. Results demonstrated that no mortality was found upto single dose of 2000 mg kg-1 b.wt. in rats even after 14 days observation. In comparison to control group MEWA at 100 and 200 mg kg-1 b.wt. showed highly significant anti-nociceptive activity against chemically (p<0.001) as well as thermally (p<0.05 and p<0.001) induced pain as compared to standard drugs, indomethacin and nalbufin, respectively. In the formalin test, both the doses of 100 and 200 mg kg-1 of extract significantly prevented increase in volume of paw edema (p<0.05 and p<0.01) both in the neurogenic and inflammatory phases. MEWA (200 and 400 mg kg-1 p.o.) also significantly prevented increase in volume of paw edema in Carrageenan test (p<0.05 and p<0.001). The results suggest that MEWA has significant analgesic and anti-inflammatory potential which may be mediated by central and peripheral mechanism.
The present study aimed to evaluate the antinociceptive and
anti-inflammatory activity of Alangium salvifolium (AS) flower in mice.
The antinociceptive activity was determined using tail immerson, acetic acid
induced writhing and formalin induced licking test. Antiinflammatory effects
were evaluated using carrageenan and formalin induced paw edema in mice. The
methanol extract (50 and 100 mg kg-1) of flower of AS followed by
chloroform extract (100 mg kg-1) produced a significant inhibition
of both phases of the formalin pain test in mice, a reduction in mice writhing
induced by acetic acid and delayed the response of mice to hot water thermal
stimulation in tail immersion test. All flowers extract of AS also produced
a substantial inhibition (nearly 50%) of carrageenan and formalin induced paw
edema. The inhibitions were similar to those produced by indomethacin, p.o.
The different alkaloids and flavonoids found in the extract could be account
for the antinociceptive and anti-inflammatory actions.
