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Articles by L.S. Bilbis
Total Records ( 5 ) for L.S. Bilbis
  M.T. Adewumi , C.H. Njoku , Y. Saidu , M.K. Abubakar , R.A. Shehu and L.S. Bilbis
  In this study serum copper, chromium and manganese were estimated in 90 diabetic patients attending the outpatient clinic of the Federal Medical Centre, Katsina, an ancient city in North-western Nigeria and the results compared to those of apparently healthy, non-diabetic volunteers of comparable age and social status. Serum glucose level of the diabetic subjects (13.91±2.87 mmol L-1) was significantly (p<0.05) higher that the value obtained for the non-diabetic subjects (4.34±0.11 mmol L-1). The serum levels of Cr (0.19±0.05 μg L-1), Cu (0.42±0.18 μg L-1) and Mn ((1.12±0.24 μg L-1) were significantly (p<0.05) lowered in diabetic subjects. About 75% of the diabetic subjects in the study area had deficient serum levels of these metals. These results suggest that the diabetic patients in the study area have low serum levels of some antioxidant mineral elements. These observations may be an indication that the diabetic subjects are predisposed to increased oxidative onslaught.
  Y. Saidu , L.S. Bilbis , M. Lawal , S.A. Isezuo , S.W. Hassan and A.Y. Abbas
  The current study reports the toxicological studies of the crude aqueous leaf extract using albino rat models. The in vivo effects of acute and sub-chronic doses of the extract on liver function and kidney function parameters were studied. The results indicated that the LD50 of the extract is > 3000 mg kg-1 body weight. There were no significant differences (p>0.05) in weight changes of the animals on different doses of the extract during both the acute and sub-chronic toxicity tests. The biochemical parameters of the animals on different doses of the extract were not significantly (p>0.05) different, except the ALT and AST that, in non-dose dependence, showed significant differences (p<0.05) in both test models. Serum globulin level of the animals on different doses during the sub-chronic test was also significantly different (p<0.05). These results indicated that the crude extract of A. chevalieri may be relatively safe for human consumption.
  S.W. Hassan , R.A. Umar , M. Lawal , L.S. Bilbis , B.Y. Muhammad , U.Z. Faruk and A.A. Ebbo
  The alkaloidal composition, histopathological and toxicity studies of alkaloid and aqueous ethanol extracts of Boscia angustifolia on biochemical indices of kidney and liver functions in rats were studied. The amount of alkaloids detected in 50 g powdered root extract of the plant was 11.44% (w/v). Renal and liver indices were significantly (p<0.05) altered at higher doses of 703.60, 1125.70 (alkaloidal extract), 839.30 and 1342.80 mg kg-1 body weight (aqueous ethanol extract). The aqueous ethanol and alkaloidal root extracts produced histopathological lesions of the liver and kidney at higher doses. These lesions include perivascular cuffs, protein cast, infiltration (kidney) and slight infiltration and perivascular cuffs (liver). There was a significant (p<0.05) dose dependent decrease in weight in the rats given higher doses of the aqueous ethanol and alkaloidal root extracts of Boscia angustifolia. The use of this plant is associated with some levels of organ toxicity.
  Y. Saidu , M. Lawal , S.A. Isezuo , R.A. Shehu , D.M. Sahabi and L.S. Bilbis
  This research studied the hypoglycaemic effect of aqueous leaf extract of Albizzia chevalieri in alloxan-induced diabetic albino rats, using activity-guided fractionation. Preliminary elucidation of the mechanism of hypoglycaemic activity was also studied. The crude aqueous leaf extract of the plant (100 mg kg-1 body weight) reduced blood glucose levels of both the diabetic and normal rats by about 30%. The hypoglycaemic agent(s) were fractionated in the hexane fraction of the aqueous extract and partitioned in the second elution fraction (H2) by column chromatography. Thin layer chromatography of H2 gave a single spot with water as the mobile phase. The preliminary results of the mechanism of action indicated that the extract did not affect the in vivo digestion of carbohydrate or intestinal absorption of glucose. It however caused significant (p<0.05) increase in the hepatic and extrahepatic glycogen store. Phytochemical screening of the crude extract indicated the presence of saponins, flavonoids, tannins, terpenes, steroids, balsams, glycosides and alkaloids. UV/visible spectral studies of H2 indicated a λmax of 320 nm. These results suggest that the hypoglycaemic effect of the extract is as a result of induction of glycogenesis.
  S.W. Hassan , M.J. Ladan , R.A. Dogondaji , R.A. Umar , L.S. Bilbis , L.G. Hassan , A.A. Ebbo and I.K. Matazu
  The leaves of Erythrophleum africanum is known in the arid land of tropical Africa to posses toxicological properties. Phytochemical, acute and sub-acute evaluation of the possible toxicity risk of E. africanum aqueous leaves extracts were investigated in this study. Phytochemical constituents detected in the leaves extracts were saponins (1.16% w/v), cardiac glycosides, tannins (0.17 true tannins and 0.23% w/v pseudotannins), flavonoid glycosides, free flavonoids and alkaloids (4.34% w/v). The Lethal Dose (LD50) of the aqueous leaves extracts was greater than 3000 mg kg-1 per os (orally) in albino rats. Sub-acute administration of the extract for 28 days resulted in significant (p<0.05) changes in some renal and liver indices at 3000 and 2000-3000 mg kg-1 body weight, respectively. Histopathological lesions of the kidney and liver in form of moderate and marked infiltration with necrosis and perivascular lymphocytic cuff were observed. The observed lesions could be due to roles played by liver and kidneys in metabolism of xenobiotics and their elimination from the body. These investigations thus seem to indicate the toxic effects of the aqueous leaves extracts of E. africanum at 2000-3000 mg kg-1. These could be attributed to the combined toxicity of the phytochemical constituents such as tannins, saponins, glycosides and alkaloids.
 
 
 
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