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Articles by L.N. Yan
Total Records ( 3 ) for L.N. Yan
  W.T. Bo and L.N. Yan
  In the last 10 years, adult living donor liver transplantation (ALDLT) has evolved in many countries of the world. Relative to cadaver liver transplantation, a living donor can curtail the time awaiting transplantation. However, the indication for ALDLT is still different between the West and the East. This article collects recent published literature on the indications for ALDLT in the West and East from 3 aspects: hepatocellular carcinoma (HCC), cirrhosis, and acute hepatic failure (AHF). The difference of ethics for ALDLT between the West and the East is also investigated. We sought to formulate the indications for ALDLT based upon the condition of our country and verified by ethical committees.
  Z.Y. Chen , L.N. Yan , Y. Zeng , T.F. Wen , B. Li , J.C. Zhao , W.T. Wang , J.Y. Yang , M.Q. Xu , Y.K. Ma and H. Wu
 

Objective: The aim of this study was to explore the indications for liver transplantation among patients with hepatolithiasis.

Patients and Methods: Data from 1431 consecutive patients who underwent surgical treatment from January 2000 to December 2006 were retrospectively collected for analysis. Surgical procedures included T-tube insertion combined with intraoperative cholangioscopic removal of intrahepatic stones, hepatectomy, cholangiojejunostomy, and liver transplantation.

Results: Nine hundred sixty-one patients who had a stone located in the left or right intrahepatic duct underwent hepatectomy or T-tube insertion combined with intraoperative cholangioscopic removal of intrahepatic stones. The rate of residual stones was 7.5%. Four hundred seventy patients who had a stone located in the bilateral intrahepatic ducts underwent surgical procedures other than liver transplantation; the rate of residual stones was 21.7%. Only 15 patients with hepatolithiasis underwent liver transplantation; they all survived. According to the degree of biliary cirrhosis, recipients were divided into 2 groups: a group with biliary decompensated cirrhosis (n = 7), or group with compensated cirrhosis or no cirrhosis (n = 8). There were significant differences in operative times, transfusion volumes, and blood losses between the 2 groups (P < .05). In the first group, 6 of 7 patients experienced surgical complications, and in the second, 8 recipients recovered smoothly with no complications. Health status, disability, and psychological wellness of all recipients (n = 15) were significantly improved at 1 year after transplantation compared with pretransplantation (P < .05).

Conclusions: Liver transplantation is a possible method to address hepatolithiasis and secondary decompensated biliary cirrhosis or difficult to remove, diffusely distributed intrahepatic duct stones unavailable by hepatectomy, cholangiojejunostomy, and choledochoscopy.
  D. Yuan , T. Lu , Y.G. Wei , B. Li , L.N. Yan , Y. Zeng , T.F. Wen and J.C. Zhao
 

Introduction: The accurate assessment of standard liver volume (SLV) is necessary for the safety of both the donor and the recipient in living donor liver transplantation. However, the accuracy of SLV formulas relates to cohorts or races. This study examined the accuracy of a simple linear formula versus previous formulas of SLV for Chinese adults.

Methods: Among 112 patients with normal liver, we created a new formula for SLV with stepwise regression analysis using the following variables: age, gender, body weight, body height, body mass index, and body surface area. The agreement between the actual liver volume (LV) and calculated LV using various formulas was prospectively evaluated among 63 living donors by paired-sample student`s t-test and Lin`s concordance correlation coefficient.

Results: A new formula was developed SLV (mL) = 949.7 × BSA (m2) − 48.3 × age − 247.4 where age was counted as 1 for those <40, 2 if 41–60, and 3 if >60 years old. The calculated LV using our formula showed no significant difference from the actual LV using the paired-samples student`s t-test (P = .653). Lin`s concordance correlation coefficient showed substantial agreement between estimated LV using our formula and actual LV. Furthermore, this study also observed an almost perfect agreement between our formula and the Yoshizumi et al formula.

Conclusion: Our formula, which accurately estimated LV among Chinese adults, may be applicable to adults of other ethnicitis.
 
 
 
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