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Articles by L.M. Faddah
Total Records ( 2 ) for L.M. Faddah
  N.M. Abdel-Hamid , L.M. Faddah , M.A. Al-Rehany and A.A. Awad
  Erectile Dysfunction (ED) is a prevalent problem among most of diabetic patients. This defect is extensively treated by Sildenafil Citrate (SC), which is a potent phosphodiesterase -5 inhibitor (PDE-5 I). The mechanism of SC in treating ED in an experimental diabetic model, in conjunction with a potent antioxidant, vitamin E (vit E) is to be elucidated. Here, we report that, whether alone or in combination with E, SC induces penile erection, mostly, through organized modulation of blood neurotransmitters, namely, Serotonin (Ser), Dopamine (Dop), Nor-Epinephrine (NEP) and Nitric Oxide (NO), in addition to potassium (K), controlled calcium (Ca) influx modulation, affecting neurotransmitters release into the circulation, without apparent impact on sodium level (Na). In the present study, Ser, Dop, NEP and NO blood levels were together, significantly up-regulated in normo-glycemic and more significantly in alloxan diabetic rats by SC treatment, an effect which was non-significantly prohibited by E combination. K level was elevated by SC in normo-glycemic, but decreased in diabetic rats. This later action was reversed by E, however, Na level was only significantly elevated in diabetic group, given SC combined with E, but Ca levels were non-significantly changed. These actions of SC elucidate-in part-the mechanism of its action and necessitate care to its impact on diseases related to autonomic neurotransmission.
  Nayira A. Abdel Baky , Azza M. Mohamed and L.M. Faddah
  In the present study the prophylactic effects of the antioxidants, β-carotene and/or N-acetyl cysteine (NAC) in ameliorating the metabolic abnormalities and oxidative damage induced cardiopathy under the effect of the flavor enhancers, monosodium glutamate (MSG) toxicity were studied. Animals were divided into 5 groups; G1: normal control, G2: MSG-treated group, Gs 3,4 and 5: animals pretreated with either NAC or β-carotene or their combination prior MSG administration, respectively. The present results revealed that, chronic administration of MSG caused metabolic dysfunction characterized by significant increases in the levels of serum glucose, total lipids, triglycerides (TG), total cholesterol (TCh) and Low Density Lipoprotein (LDL) and a decrease in the high density lipoprotein (HDL), parameters have important role in MSG induced cardiovascular disorders. The adverse effects of MSG may be related to an imbalance between the oxidant and antioxidant systems. This was indicated by marked increased levels of serum nitric oxide (NO) accompanied by pronounced increased level of thiobarbituric acid reactive substances (TBARS, marker of lipid peroxidation) and decreased levels of the antioxidants, L-ascorbic acid, glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) in cardiac tissue versus normal animals. Significant inhibition in cardiac Na+/K+ ATPase with increase in serum activities of creatine phophokinase (CPK) and aspartate aminotransferase (AST) were also observed in MSG treated animals as biomarker enzymes of cardiac tissue damage. This result was supported by myocardial infarction (necrotic lesion) observed by histopathological examination. Administration of either β-carotene or NAC prior MSG injection significantly modulated the alteration in most of the previously mentioned parameters to near their normal levels. Administration of synergistic combination of the these antioxidants showed the most significant effect as it has the ability to restore all of the studied parameters to their normal levels. The biochemical results were supported by the improvement in histological architecture of heart tissue, implicating that these antioxidants either alone or their combination may protect heart from the harmful effects of cardio-toxic agents.
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