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Articles by L. Zarei
Total Records ( 2 ) for L. Zarei
  L. Zarei , E. Farshadfar , R. Haghparast , R. Rajabi and M. Mohammadi Sarab Badieh
  The objective of this study was to evaluate the ability of several selection indices to identify drought resistant cultivars under field and laboratory conditions in Kermanshah, Iran. Twenty bread wheat genotypes differing in yield performances were evaluated using a RCBD design with three replications under two different environments (irrigated and rein-fed) during 2004-2005 growing season. Grain yield of the genotype in the both conditions, Stress Tolerance Index (STI), was calculated for each genotype. Moreover Proline amino acid concentration (PC) in flag leaf of each genotype was also measured in grain filling stage in the stressed condition. Cell Membrane Stability (CMS) of leaf tissues in seedling stage was calculated for each genotype grown in the pots in greenhouse. Germination Stress Index (GSI), coleoptile length and root length, number of roots, Promptness Index in Stress (PIS) and non-stress (PINS) condition were recorded in the controlled condition of laboratory by using a 2x20 factorial experiment within completely randomized design with three replications under two different stress and non-stress (normal) water regimes. The result of analysis of variance exhibited highly significant difference among the genotypes for the most of the traits. Drought stress induced by PEG (polyethylene glycol) decreased all of the traits. Root length was the most sensitive to drought stress. Correlation analysis indicated strong association between STI and CMS and PC. It was inferred from the study that the greater drought tolerance corresponded to the greater cell membrane stability and proline accumulation. Also, highly significant correlation was observed between GSI, STI and PIS. The results imply that these criteria may be screened for indirect selection of drought tolerance in the initial stages of the bread wheat growth.
  B. Ilkhanizadeh , A. Mehrshad , A. Seddighnia and L. Zarei
  Objective: Artemisia annua L. (Asteraceae) (artemisinin) has special antitumor activity against melanoma, breast, ovarian, prostate, central nervous system and renal cancer cell lines. The present study was conducted to compare effects of free and niosomal formulation of artemisinin on Chronic Myelogenous Leukemia (CML) using K562 cell line. Materials and Methods: Different concentrations of artemisinin were prepared using spectrophotometer in 195 nm wavelength. Two different methods of reverse phase evaporation and ether injection were adopted to prepare the niosomes formulations. Encapsulation, in vitro release, in vitro cytotoxicity determination and the K562 cells viability rates were assessed. Results: The percentage of encapsulation for niosome formulation obtained with reverse phase evaporation and ether injection methods were 87.27±0.93 and 74.9±4.2, respectively. The rate of the artemisinin release across the dialysis membrane was significantly slower for artemisinin-loaded niosomes than that of the free artemisinin (p<0.05). The percentage of K562 cells apoptosis in free artemisinin was significantly higher than that of the niosomal formulations (p<0.05). The niosomal formulations showed significantly more influence than that of the free artemisinin (p<0.05). Conclusion: The use of niosomal formulation of artemisinin could effectively improve its therapeutic index, release rate and apoptosis influence.
 
 
 
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