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Articles by L. Shi
Total Records ( 4 ) for L. Shi
  L. A. Bazzano , L. J. Lee , L. Shi , K. Reynolds , J. A. Jackson and V. Fonseca

Aims We systematically analysed evidence from randomized controlled trials (RCTs) examining the safety and efficacy of neutral protamine Hagedorn (NPH) insulin and glargine in the management of adults with Type 2 diabetes.

Methods Studies were identified by searching medline (1966–March 2007), embase (1974–2007), American Diabetes Association abstract database and the Cochrane Central Register of Controlled Trials using Medical Subject Headings (MeSH) diabetes mellitus, Type 2, insulin, insulin isophane, hypoglycaemic agents and the keywords glargine and NPH. Data on study design, participants, fasting plasma glucose (FPG), glycated haemoglobin (HbA1c), body weight and hypoglycaemia were independently abstracted by two investigators using a standardized protocol.

Results Data from a total of 4385 participants in 12 RCTs were pooled using a random-effects model. The mean net change (95% confidence interval) for FPG, HbA1c and body weight for patients treated with NPH insulin as compared with glargine was 0.21 mmol/l (−0.02 to 0.45), 0.08% (−0.04 to 0.21) and −0.33 kg (−0.61 to −0.06), respectively, with negative values favouring NPH and positive values favouring glargine. More participants experienced symptomatic and nocturnal hypoglycaemia on NPH than glargine, but there was no significant difference in confirmed or severe episodes.

Conclusions We identified no difference in glucose-lowering between insulin glargine and NPH insulin, but less patient-reported hypoglycaemia with glargine and slightly less weight gain with NPH in adults with Type 2 diabetes.

  X. Yu , X.X. Huang , W.J. Liu , Y. Fang , L. Shi , W.T. Xing , C.W. Tang and M.A. Brown
  The genetic variability and genetic relationship of the fifteen sheep breeds were studied. The genotypes of 14 indigenous Chinese sheep breeds and one crossbreed of wild sheep were investigated using 13 microsatellite DNA markers recommended by the Food and Agriculture Organization of the United Nations (FAO) and the International Society of Animal Genetics (ISAG) through PCR. The allele frequency, heterozygosity and Genetic Differentiation Index (Fst) were computed to estimate the genetic variation of each population. To determine the genetic relationships among the breeds, phylogenetic trees were constructed based on Nei’s genetic distance using the unweighted pair-group method with arithmetic mean and neighbor-joining method. A total of 15 breeds were clustered into three groups. The first group included Altay sheep and Duolang sheep, the second group was very large and complicated, the third group was a Kazark sheep. The thirteen microsatellite loci were effective markers for the analysis of genetic relationship among sheep breeds. In addition, genetic distance among groups is not according with their geographic distribution and groups or breeds with low production performance can easily impacted by breeds with better production performance. As for the results, it may be result from applying on artificial insemination and extension of commercial cross breeding technique in sheep production system recent years in China.
  C.W. Xiao , Y.S. Wang , L. Shi and H. Guo
  Based on Least Square Support Vector Machine (LSSVM) algorithm, a Sound Quality Prediction (SQP) model of vehicle interior noise during acceleration is presented in this study. The objective psychoacoustic parameters and subjective annoyance results are used as the input and output of the model, respectively. With correlation analysis, some psychoacoustic parameters, such as loudness, sharpness, roughness, articulation index and tonality, are selected for the modeling. The estimated values of unknown samples with the LSSVM SQP model are highly correlated with the subjective annoyance values, which has a higher accuracy than that with Multiple Linear Regression (MLR) model. Results show that the proposed LSSVM SQP model has good generalization ability and can be applied to the sound quality prediction of vehicle interior noise during acceleration.
  A.K. Heller , L. Shi , J.S. Brenizer and M.M. Mench

Neutron computed tomography is an important imaging tool in the field of non-destructive testing and in fundamental research for many engineering applications. Contrary to X-rays, neutrons can be attenuated by some light materials, such as hydrogen, but can penetrate many heavy materials. Thus, neutron computed tomography is useful in obtaining important three-dimensional information about a sample's interior structure and material properties that other traditional methods cannot provide. The neutron computed tomography system at the Pennsylvania State University's Radiation Science and Engineering Center is being utilized to develop a water quantification technique for investigation of water distribution in fuel cells under normal conditions. A hollow aluminum cylinder test sample filled with a known volume of water was constructed for purposes of testing the quantification technique. Transmission images of the test sample at different angles were easily acquired through the synthesis of a dedicated image acquisition computer driving a rotary table controller and an in-house developed synchronization software package. After data acquisition, Octopus (version 8.2) and VGStudio Max (version 1.2) were used to perform cross-sectional and three-dimensional reconstructions of the sample, respectively. The initial reconstructions and water quantification results are presented.

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