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Articles by L. Li
Total Records ( 5 ) for L. Li
  J.A. Ogejo and L. Li
  The objective of this study was to assess the quantity and quality of biogas produced by co-digesting flushed dairy manure (FDM) and turkey processing wastewater (TPW). An attached growth digester with working volume of 15 L and a 3 L head space was operated at a 5 d hydraulic retention time using five feed mixes containing 100, 67, 50, 33, and 0% FDM by volume. The biogas yield ranged from 0.072 to 0.8 m3 [g VS−1] and the methane content (quality) of the gas ranging from 56% to 70%. Both the quantity and quality of the biogas increased as the proportion of TPW in the feed increased. An energy balance for the digester based on a dairy farm with 150 animals, showed that augmenting FDM with TPW at 1:1 and 1:2 ratios, feeds C and D, respectively, produced biogas with net positive energy to all year round. The gas produced was enough to run a 50 kW generator to produce electricity for about 5.5 and 9 h for the 1:1 and 1:2 feed mixes. However, the economics were not favorable if the benefits of the digester are based only on the value electricity to be produced. Either, other possible revenues such as carbon credit, renewable energy credits, green tags for electricity, putting a value to the environmental benefits of AD should be considered or subsidies from grants or other incentives programs to make the system economically viable.
  C. L Thompson , S. J Plummer , L. S Acheson , T. C Tucker , G Casey and L. Li

Two recent genome-wide association studies (GWAS) identified three common variants in SMAD7 (rs4464148, rs4939827 and rs12953717) that confer modest susceptibility to colorectal cancer. Here, we replicated the association of rs4464148 with colon cancer in a population-based case–control study (561 cases and 721 controls). Compared with the TT genotype, those with CT and CC had an adjusted odds ratio (OR) and 95% confidence interval of 1.06 (0.82–1.38) and 1.86 (1.17–2.96), respectively (Ptrend = 0.04). However, stratified analyses revealed that this association was limited to women only [OR = 1.25 (0.88–1.78) for CT and OR = 2.76 (1.53–4.98) for CC, Ptrend = 0.002, Pinteraction = 0.08], which was not noted in any GWAS. Similarly, we found evidence for association with both rs4939827 and rs12953717 in women only (P = 0.007 in dominant rs4939827 model and P = 0.015 in recessive rs12953717 model), but not in men (P > 0.05) and evidence of an interaction with gender (P = 0.015 for rs4939827 and P = 0.061 for rs12953717). Similar effect modification was found in haplotype analyses. Our data add evidence supporting these genetic variants as markers predisposing to colon cancer, specifically in women.

  F. Bragg , L. Li , M. Smith , Y. Guo , Y. Chen , I. Millwood , Z. Bian , R. Walters , J. Chen , L. Yang , R. Collins , R. Peto , Y. Lu , B. Yu , X. Xie , Y. Lei , G. Luo and Z. Chen


To examine the relationship of self-reported diabetes, and of random blood glucose levels among individuals without known diabetes, with the prevalence of cardiovascular disease in Chinese adults.


We examined cross-sectional data from the China Kadoorie Biobank of 0.5 million people aged 30-79 years recruited from 10 diverse regions of China in the period 2004-2008. Logistic regression was used to estimate the odds ratios of prevalent cardiovascular disease associated with self-reported diabetes, and with measured random blood glucose levels among participants with no history of diabetes, adjusting simultaneously for age, sex, area, education, smoking, alcohol, blood pressure and physical activity.


A total of 3.2% of participants had self-reported diabetes (men 2.9%; women 3.3%) and 2.8% had screen-detected diabetes (men 2.6%; women 2.8%), i.e. they had no self-reported history of diabetes but a blood glucose level suggestive of a diagnosis of diabetes. Compared with individuals without a history of diabetes, the odds ratios associated with self-reported diabetes were 2.18 (95% CI 2.06-2.30) and 1.88 (95% CI 1.75-2.01) for prevalent ischaemic heart disease and stroke/transient ischaemic attack, respectively. Among participants without self-reported diabetes there was a positive association between random blood glucose and ischaemic heart disease and stroke/transient ischaemic attack prevalence (P for trend <0.0001). Below the diabetic threshold (<11.1 mmol/l) each additional 1 mmol/l of random blood glucose was associated with 4% (95% CI 2-5%) and 5% (95% CI 3-7%) higher odds of prevalent ischaemic heart disease and stroke/transient ischaemic attack, respectively.


In this adult Chinese population, self-reported diabetes was associated with a doubling of the odds of prevalent cardiovascular disease. Below the threshold for diabetes there was still a modest, positive association between random blood glucose and prevalent cardiovascular disease.

  Y.N. Min , H.L. Li , L. Li , Z.Y. Niu , J.J. Wang , S.K. Liu , J. Zhang and F.Z. Liu
  This experiment was conducted to evaluate the effects of dietary DDGS levels on small intestinal morphology of broilers. A total of 720 Cobb 48 male broilers were used in this experiment. Birds were fed diets formulated to contain 0, 5, 10, 15, 20 and 25% DDGS, respectively for a period of 6 week. On day 21 and 42, significant differences were observed in Villus Height (VH), Crypt Depth (CD) and the ratio of villus height to crypt depth (VCR) in duodenum, jejunum and ileum except for ileum on day 42. About 10-15% DDGS inclusion level showed better VH, CD and VCR for broiler intestinal morphology. Therefore, dietary added with DDGS can improve intestinal morphology, up till to 15% DDGS concentrations were considered to be suitable for broiler starter and grower age.
  J. Wen , L. Li , J. Chen , S. Ji , C. Zheng and Z. Liu

Objective: To observe the influence of the Tripterygium wilfordii Hook F (T II) on the blood concentration of tacrolimus and analyze the impact of this effect.

Method: Twenty-two renal transplant receipts taking tacrolimus combined with the T II were selected for this study. We analyzed the blood concentrations and the rate of concentration compared with dosage (C/D rate) pre- and postcombination over 6 months. All cases underwent the CYP3A5 genotype test.

Result: The concentrations of tacrolimus were raised to a certain degree after the combination in all the cases. The first-time elevation differed from 1 week to 4 months. The C/D rate increased by 1.7 to 7.2 times with most evaluated C/D rates ranging from 1.8 to 3.8. The elevated C/D rate of the subgroup of CYP3A5 1*/1* and 1*/*3 (n = 10) contrasted with the *3/*3 genotype subgroup (n = 12: 2.99 ± 1.71 vs 2.55 ± 1.07; P = .472). The mycophenolate mofetil subgroup (n = 17) was not contrasted to the mizoribine subgroup (n = 5: 2.85 ± 1.51 vs 2.31 ± 0.26; P = .498).

Conclusion: T II considerably increased the blood concentration and the C/D rate of tacrolimus. The degree of increase was probably not related to the CYP3A5 genotype and the combination of immunosuppressive agents.
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