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Articles by L. Gao
Total Records ( 2 ) for L. Gao
  Q. Wan , F. Wang , Q. Guan , Y. Liu , C. Wang , L. Feng , L. Feng , L. Gao and J. Zhao
  Aims Lipotoxicity has recently been shown to be an important risk factor underlying the pathogenesis of pre-diabetes. However, clinical evidence supporting the treatment of pre-diabetes by improving lipotoxicity is lacking. Here, we conducted an open-label, randomized, controlled trial to investigate whether fenofibrate, the widely used hypolipidaemic agent, might benefit pre-diabetes, with metfomin and diet control, the recommended intervention methods, as positive controls. Methods Newly diagnosed pre-diabetes patients (n = 120) with hypertriglyceridaemia (plasma triglyceride levels between 1.8 and 4.5 mmol/l) were randomly assigned by computer-generated randomization sequence to either control group (no intervention), fenofibrate group (200 mg once a day), metformin group (500 mg three times a day) or diet-controlled group (diet recommendation). Plasma biochemistry examination was performed every 2 months. The primary endpoint was the outcome of the natural course of pre-diabetes, evaluated by oral glucose tolerance test after 6-month follow-up. Results Twenty subjects in the fenofibrate group, 24 subjects in the metformin group and 25 subjects in both the diet-controlled group and the control group finished the trial. Fenofibrate, metformin and diet control had protective effects on hypertriglyceridaemic pre-diabetes, evidenced by 53.3, 70 and 30% participants regressed to normoglycaemia, respectively. The effects of fenofibrate and metformin were comparable (P > 0.05), while diet control was less effective (P < 0.05). Liver damage occurred in six subjects in the fenofibrate group and gastrointestinal symptoms occurred in four subjects in the metformin group. No serious adverse events occurred. Conclusion Controlling lipotoxicity by fenofibrate could effectively ameliorate the natural course of hypertriglyceridaemic pre-diabetes.
  C. Chang , L. Gao , H. Kou , X. Liu , Z. Qin and G. Xu
  An integrity batch report protocol based on the waiting stack is proposed, which aims at solving the bottleneck problem of the Trusted Platform Module (TPM) signature of integrity report. In the protocol, integrity attestation requests are placed sequentially in a waiting stack with constant head part and varying length. The TPM processes the integrity batch report one after another and thus the flexibility problem of trusted gateway can be solved efficiently. This study also proposes a data compressing method based on the Merkle tree to reduce the communication complexity in processing integrity batch report. The length of fresh number connection string transferred to the challenger can be compressed from mx20 bytes to log2mx20 bytes. The laboratory result indicates that the responding capacity of gateway adopting integrity batch report protocol is prior to adopting TCG integrity report protocol and the processing capacity of gateway can be improved from 1~3.3 to 32~256 times per second.
 
 
 
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