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Articles by L Wagman
Total Records ( 1 ) for L Wagman
  Z Meng , Y Wang , L Wang , W Jin , N Liu , H Pan , L Liu , L Wagman , B. M Forman and W. Huang
 

Liver repair is key to resuming homeostasis and preventing fibrogenesis as well as other liver diseases. Farnesoid X receptor (FXR, NR1H4) is an emerging liver metabolic regulator and cell protector. Here we show that FXR is essential to promote liver repair after carbon tetrachloride (CCl4)-induced injury. Expression of hepatic FXR in wild-type mice was strongly suppressed by CCl4 treatment, and bile acid homeostasis was disrupted. Liver injury was induced in both wild-type and FXR–/– mice by CCl4, but FXR–/– mice had more severe defects in liver repair than wild-type mice. FXR–/– livers had a decreased peak of regenerative DNA synthesis and reduced induction of genes involved in liver regeneration. Moreover, FXR–/– mice displayed increased mortality and enhanced hepatocyte deaths. During the early stages of liver repair after CCl4 treatment, we observed overproduction of TNF and a strong decrease of phosphorylation and DNA-binding activity of signal transducer and activator of transcription 3 in livers from FXR–/– mice. Exogenous expression of a constitutively active signal transducer and activator of transcription 3 protein in FXR–/– liver effectively reduced hepatocyte death and liver injury after CCl4 treatment. These results suggest that FXR is required to regulate normal liver repair by promoting regeneration and preventing cell death.

 
 
 
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