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Articles by Kuldeep Dhama
Total Records ( 3 ) for Kuldeep Dhama
  Amit Kumar Verma , Mani Saminathan , Neha , Ruchi Tiwari , Kuldeep Dhama and Shoor Vir Singh
  Glanders is a contagious and highly fatal zoonotic disease affecting horses, donkeys and mules as well as man leading to formation of nodules and ulcerations in the upper respiratory tract and lungs. This is a notifiable disease under Glanders and Farcy Act, 1899. The disease is caused by Burkholderia mallei, a gram negative bacteria, non-spore forming, non-motile rod bacterium and is a facultative intracellular pathogen. The disease has been eradicated from many countries by testing and destruction diseased horses and restriction of import of animals. However, the disease is endemic in Africa, Asia, Mongolia, Middle East, Central and South America. In India, major glanders outbreaks were reported between 1976 to 1982 from different parts of the country. Later, sporadic cases were reported in 1988, 1990 and 1998. India was remained free of glanders for 8 years until recent re-emerging outbreaks started from 2006 to 2011. The occurrence of the disease leads to international trade restrictions. Glanders is primarily a disease of equines which causes chronic disease in horses and acute disease in donkeys and mules. Human is accidental host and the disease usually results from occupational exposure. Though the organism is susceptible to various antibiotics in vitro treatment is difficult and needs longer course with combination of antibiotics upon early diagnosis. It can be used as a biological weapon and has been classified by the Centers for Disease Control and Prevention (CDC) as a category B bio-threat agent and at present no vaccine is available for this bacterium either in humans or animals. This review describes this important disease covering its etiology, epidemiology, transmission, clinical signs, post-mortem lesions, public health significance, diagnosis, treatment and prevention and control strategies to be adapted to combat this deadly zoonotic pathogen.
  Anu Rahal , Mahima , Amit Kumar Verma , Amit Kumar , Ruchi Tiwari , Sanjay Kapoor , Sandip Chakraborty and Kuldeep Dhama
  At present, almost every third person in the society is under stress and having chronic disorders like diabetes, arthritis, allergy, cardiovascular disease, fatigue and even cancer. Recently, there is decline in the physical and mental capabilities along with the social values. So this certainly should raise the alarms as to why such deterioration is taking place in the society or what are the changes in the lifestyle that might have a role direct/indirect in evolution of such changes? Vegetable is an immense store of active chemical compounds and considered as the cheapest and most easily available sources of carbohydrate, fiber, proteins, vitamins, minerals and amino acids. The intake of green and leafy vegetables lowers the risk of chronic diseases, cardiovascular diseases, anemia, cancer, oxidative stress, diabetes, weight gain etc. In recent time, vegetables have also been identified as safe and economic expression system for producing the recombinant proteins including the vaccines against many infectious diseases like hepatitis B, malaria, rotavirus, HIV, Helicobacter pylori, pestedes petits ruminants etc. However, besides the beneficial effect, contaminated and raw vegetables harbors pesticide residues and many pathogenic microbes viz., norovirus, Salmonella, E. coli, Shigella, Listeria monocytogens and also prove to be an excellent source of disease outbreaks. The present review highlights the phytonutrients and neutraceuticals in fruits and vegetables; their medicinal and health benefits for humans and their domestic as well as companion animals along with their fruitful practical applications and perspectives like bioreactor for producing vaccine along with the methods that can increase their nutritional benefits.
  A.K. Singh , A.K. Verma , Neha , Ruchi Tiwari , K. Karthik , Kuldeep Dhama and S.V. Singh
  By 2050 to feed the estimated human population of around 9 billion, there is requirement of 50% increase the food production, which can only be fulfilled by clean, healthy and sustainable food animal production. Livestock industry is facing considerable economic losses due to infectious diseases. So an effective control strategy is need of today to control these infectious diseases and contribute in augmentation of livestock production. Parasitic diseases have a major impact on livestock production, reproduction and hence economy. Protozoan parasites are major causes of human and animal disease causing extensive morbidity and mortality, particularly parasitic disease in tropical and sub-tropical climatic regions. Many protozoal parasitic diseases are zoonotic. Limiting the impact of parasitism in both man and livestock relies almost exclusively on the use of antiparasitic drugs. Development of resistance towards chemotherapeutic agents has forced the scientist to discover some alternative for control of parasitic diseases. Recent advances in immunology and biotechnology have sensitized the scientists or researchers to develop the newer and safer vaccines for control of parasitic diseases. This review is intended to provide state-of-art information to the reader with an overview on the trends, advances and perspectives in vaccines and vaccinology against important parasitic diseases of livestock and poultry viz., coccidiosis, anaplasmosis, giardiosis, babesiosis, Neospora infection, toxoplasmosis, theleriosis, sarcocyst infestation, leishmaniasis, trypanosomiasis and trichomoniasis, which altogether play crucial role in the prevention of protozoan parasitic diseases of animals.
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