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Articles by Krishnan Kannabiran
Total Records ( 2 ) for Krishnan Kannabiran
  Deepika T. Lakshmipathy and Krishnan Kannabiran
  Problem statement: Dermatophytes have developed resistance to the existing antifungal antibiotics. As a part of our continuous search we had isolated, identified and characterized actinomycetes from the halophilic environment having antagonistic activity against the dermatophytes namely Trichophyton, Microsporum and Epidermophyton. Approach: Actinomycetes were isolated from the soil sample collected from the Ennore saltpan region, Chennai, India and screened for antidermatophytic secondary metabolite production by well diffusion method. Four dermatophytes Trichophyton rubrum [MTCC 3272], Trichophyton mentagrophytes [MTCC 7687], Microsporum gypseum [MTCC 2819] and Epidermophyton floccosum [MTCC 7880] were used to study its susceptibility to the isolated actinomycetes. Actinomycetes which showed antidermatophytic activity were subjected to cultural characterization with respect to aerial and substrate mycelia color, diffusible and melanin pigment production and the growth of the organisms on different media. Further the micro morphological characteristics such as spore surface ornamentation and spore chain morphology determined by Scanning Electron Microscopic (SEM) analysis also suggested that the isolates belonged to the genus Streptomyces. The isolates were also tested for utilization of various carbon and nitrogen sources, degradation of complex compounds, sensitivity to antibiotics and inhibitory compounds. Results: All the 3 isolates exhibited different cultural and morphological characteristics. Based on the cultural characters and morphology they were assigned to the genus Streptomyces. The three isolates produced an inhibition zone of 30-31 mm on an average, utilized a wide range of carbon and nitrogen sources, degraded almost all the complex compounds and exhibited a broad spectrum of antibiotic resistance. They were designated as Streptomyces sp. DKDVIT1, Streptomyces sp. DKDVIT2 and Streptomyces sp., DKDVIT3. Conclusion: The Streptomyces sp. isolated from the Ennore saltpan of Bay of Bengal exhibited potential antidermatophytic activity. The extraction and characterization of secondary metabolites from these Streptomyces may be used as a lead compound/therapeutic agent for dermatophytosis.
  Venkatesan Gopiesh Khanna and Krishnan Kannabiran
  The antimicrobial activity of saponin fraction from the roots of Hemidesmus indicus was evaluated against pathogenic bacteria and fungi in an in vitro condition by agar diffusion assay. Pure saponin extract exhibited remarkable antimicrobial activity against Staphylococcus aureus, Salmonella typhi, Klebsiella pneumoniae, Aspergillus flavus, Aspergillus fumigatus and Aspergillus niger. The present study suggests that the saponin fraction possesses significant antibacterial activity. It can be concluded from this study, saponin may be a phytochemical of choice to develop as a potential antimicrobics against pathogenic microorganisms.
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