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Articles by Krishnamoorthi Vasudevan
Total Records ( 2 ) for Krishnamoorthi Vasudevan
  Shanmugam Manoharan , Simon Silvan , Krishnamoorthi Vasudevan and Subramanian Balakrishnan
  Piper longum (Piperaceae family) is used in Indian traditional medicine as a remedy for various disorders including diabetes mellitus. The aim of the present study was to investigate the antihyperglycemic and antilipidperoxidative effects of ethanolic extract of Piper longum dried fruits (PLEFet) in alloxan induced diabetic rats. Diabetes mellitus was induced in overnight fasted (12 h) Wistar rats by single intraperitoneal injection of freshly prepared solution of alloxan monohydrate (150 mg kg-1 bw) in physiological saline. The blood glucose level, carbohydrate metabolizing enzymes and the status of lipid peroxidation and antioxidants were assayed using specific colorimetric methods. Oral administration of PLEFet has shown significant antihyperglycemic, antilipidperoxidative and antioxidant effects in diabetic rats. PLEFet also corrected the metabolic alterations observed by the activities of several carbohydrate metabolizing enzymes (hexokinase, glucose-6-phosphatase, glucose-6-phosphate dehydrogenase, fructose 1.6-bisphosphatase and glycogen phosphorylase) in alloxan induced diabetic rats. The antihyperglycemic effect of PLEFet is comparable to that of the standard reference drug, glibenclamide. Present results indicate that PLEFet has potent antihyperglycemic and antilipidperoxidative effects in alloxan induced diabetic rats. PLEFet can therefore be used as an alternative remedy for diabetes and oxidative stress associated diabetic complications.
  Krishnamoorthi Vasudevan , Divianathan Sophia , Subramanian Balakrishnan and Shanmugam Manoharan
  Different parts of the Ficus racemosa plant products are employed in the Indian traditional medicine for the treatment of several disorders including diabetes mellitus. Our aim was to investigate the antihyperglycemic and antilipidperoxidative effects of aqueous and ethanolic extracts of Ficus racemosa bark (FrABet and FrEBet) in alloxan induced diabetic rats. Oral administration of FrABet and FrEBet at a dose of 400 and 300 mg kg-1 bw, respectively showed potent antihyperglycemic and antilipidperoxidative effects in alloxan induced diabetic rats. The extracts also improved the antioxidants defense system in alloxan induced diabetic rats. The FrEBet showed better effect than glibenclamide whereas the effect of FrABet was much comparable to that of glibenclamide (reference drug). Our results indicate that FrABet and FrEBet have prominent antidiabetic and antilipidperoxidative effects in experimental diabetes and can therefore be used as an alternative remedy for the treatment of diabetes mellitus and its complications.
 
 
 
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