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Articles by Krishna Murti
Total Records ( 4 ) for Krishna Murti
  Krishna Murti , Manoj Kumar Sethi , Akalanka Dey , Chandra Sekhar Lal , Krishna Pandey and Pradeep Das
  This study compares the change in BMI, fasting and postprandial blood glucose, glycosylated haemoglobin (HbA1c), Glomerular Filtration Rate (GFR), serum creatinine, blood urea and lipid profile levels when two different therapies (group A = metformin+glimepiride) and group B = metformin+glimepiride+voglibose) are given to diabetic patients to compare efficacy of voglibose as an add-on therapy. This study was a 10 months prospective, open-label comparative study. Type II diabetic subjects, aged >18 years were selected and were divided into group A and B. All the parameters were evaluated before the treatment and reassessed after 3 months of treatment. Group A and B was having significant decrease in BMI with p<0.017 and p<0.049, respectively. In both of the groups glucose triad levels decreased significantly as p value found less than 0.05. There was no effect was found over blood urea level. Protective function of kidney observed when voglibose added. Evidence of controlling lipid profile also observed in triple drug therapy as p-value was <0.05. The add-on therapy using voglibose in dual therapy including glimepiride and metformin showed a very significant benefit in controlling the glucose triad levels (HbA1C, fasting plasma glucose and postprandial glucose level) when compared to dual therapy. Voglibose has an effect to decrease Total Cholesterol (TC), triglycerides (TGs) and Low Density Lipoproteins (LDL) level and increase HDL significantly. There was no effect was found on blood urea level.
  Krishna Murti , Vijay Lambole , Vipul Gajera and Mayank Panchal
  Backgrownd: Ficus religiosa (Family-Moraceae) which is commonly known as Pepal tree is abundantly distributed throughout in India. Ficus religiosa leaves are reported to have wound healing, Anti-inflammatory, analgesic, anti lipid- peroxidation activity. Hence the present study was aimed to investigate the wound healing activity by excision and incision wound models. Materials and Methods: The wound-healing activity of Ficus religiosa extracts in ointment form (5 and 10%) was evaluated on Wistar albino strain rats of either sex. Povidine iodine 5% was used as Standard drug. The healing of the wound was assessed by the rate of wound contraction, period of epithelialization and skin breaking strength. Results: Both the extracts as ointments (5 and 10%) of Ficus religiosa root extracts promoted the wound-healing activity significantly in all the wound models studied. High rate of wound contraction, decrease in the period for epithelialisation, high skin breaking strength et al high hydroxyproline content were observed in animals treated with 10% root extract ointment when compared to the control group of animals. Conclusion: Therefore, root extracts of Ficus religiosa in the form of 10% ointment promotes wound-healing activity better than the former concentration, 5%.
  Krishna MurtI , Mayank Panchal , Poonam Taya and Raghuveer Singh
  The present review describes the morphological, phytochemical and pharmacology aspects of Scoparia dulcis (Scrophulariaceae). Scoparia dulcis (commonly known as sweet broomweed) is a perennial herb widely distributed in tropical and subtropical regions. Broomweed is a common annual herb in Suriname growing up to 2 m in height. Scoparia has been used as a remedy for treating diabetes mellitus in India and hypertension in Taiwan. It is traditionally used in treatment of diabetes, dysentery, earache, fever, gonorrhea, headaches, jaundice, snake bite, stomach problems, toothache, warts. So, the present paper enumerates an overview of phytochemical and pharmacological properties which may help the researchers to set their minds for approaching the efficacy and potency of herb.
  Krishna Murti , Mayank A. Panchal , Vipul Gajera and Jinal Solanki
  Context and Background: The present review describes the morphological, phytochemical and pharmacology aspects of Matricaria recutita (Asteraceae). Chamomile, Matricaria recutita L., is a well-known medicinal plant in folk medicine cultivated all over the world. Chamomile essential oil is widely used in pharmaceutic, cosmetic and food industries. The pharmacological effect of chamomile is mainly connected with its essential oil for its spasmolytic, antimicrobial and disinfective properties. Results: The pharmacognostical and Pharmacological activity has been studied with phytochemistry. Conclusion: From the study, it was concluded that antidiabetic activity on other parts of the plant has not been carried out. Therefore, there is a need and opportunity to carry out the antidiabetic activity on other parts of the plant.
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