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Articles by Koh Kawasumi
Total Records ( 7 ) for Koh Kawasumi
  Megumi Fujiwara , Toko Sato , Hiroyuki Tazaki , Ichiro Yamamoto , Koh Kawasumi and Toshiro Arai
  Hyperlipidemia refers to increase of triglyceride (TG) and/or total cholesterol (T-cho) in blood. Fatty Acids (FAs) have important roles in the lipid metabolism. The aim of this study was to determine the FA composition of plasma lipid fractions in dogs with hyperlipidemia and to evaluate the FA composition as a new diagnostic marker for obesity at early stage. Thirty-nine dogs were classified into healthy or hyperlipidemia based on the criteria to diagnose hyperlipidemia. The blood biochemical values, such as TG, T-cho, glucose, insulin, adiponectin and Non-Esterified Fatty Acid (NEFA) were measured. FA composition profile was performed on GC/MS system. The values of plasma TG, insulin and NEFA of the hyperlipidemia group were significantly higher than that of control group. Hyperlipidemia group tended to show lower concentration of adiponectin. It was found that only the levels of TG and NEFA, but not T-cho increased significantly in early stage of hyperlipidemia. In hyperlipidemia group, percentages of myristic acid (C14:0), parmitoleic acid (C16:1) and oleic acid (C18:1) increased in total FAs. And the percentage of C18:1 increased in NEFA. Indeed, the higher level of insulin and lower adiponectin concentration were seen in hyperlipidemia group. These results suggest that appearance of insulin resistance may be the result of increases of certain FAs in early stage of insulin resistance.
  Nobuko Mori , Gebin Li , Megumi Fujiwara , Shingo Ishikawa , Koh Kawasumi , Ichiro Yamamoto and Toshiro Arai
  The prevalence of obese cats has increased because of over calorie diet and physical inactivity. Obesity has been found to be associated with oxidative stress and Reactive Oxygen Species (ROS). Unfortunately oxidative stress status at the early phase of obesity in high fat fed cats is not well understood. The objectives of this study were (1) To evaluate lipid and glucose metabolism using enzymatic, hormonal and oxidative stress biomarkers at the early obese phase of cats fed on a high-fat diet and (2) To identify rapidly changing variables to use as a diagnostic marker for lipid metabolic disorders in cats. Total 13 domestic female cats were divided into two groups which were fed on control and high-fat diet for eight weeks, respectively. After the feeding period, they were compared in metabolic variables and oxidative stress markers in plasma and tissues. As results, High-fat diet including much long chain fatty acids promoted rapid changes in lipid metabolism, particularly accelerated β-oxidation of fatty acids and oxidative stress in the liver of the cats. G6PD, GPx and SOD were increased in the liver. Insulin resistance was not apparent at the early phase of obesity in cats. Plasma activities of SOD also increased at the early phase of obesity in cats. Remarkable alternation for oxidative stress in liver was observed at the early phase of obesity in cats fed on high fat diet and SOD may be a potential marker of the early phase of obesity in cats.
  Koh Kawasumi , Yuki Okada , Nanae Kashiwado , Eiji Iwazaki , Nobuko Mori , Ichiro Yamamoto and Toshiro Arai
  The efficiency of licorice flavonoid supplement as anti-obesity substance was investigated in 14 client-owned dogs. This flavonoid supplement reduced whole and visceral fat in overweight humans. All experimental dogs were given the supplement at a dose of 10 mg kg-1 day-1 in the evening with food for 8 weeks. After 8 weeks post-administration, the body weight was decreased in 11 animals (78.6%). The decreasing rate was 2.51±0.6% (Mean±SE). Serum glucose (GLU), Triglyceride (TG), Malondialdehyde (MDA) concentrations and aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Glutathione peroxidase (GSHPx) activities were decreased but the changes were not statistically significant. On the contrary, serum adiponectin (ADN) concentrations, though statically significance was not seen, tended to increase after 8 weeks post-administration of the supplement compared to those in baseline. In conclusion, the licorice flavonoid supplement was suggested to show anti-obesity effect accompanied with improvement of lipid metabolism in tissues of dogs.
  Makoto Habara , Makoto Tamanuki , Shingo Ishikawa , Hiroshi Takemitsu , Nobuko Mori , Yuki Okada , Nobuhiro Nakao , Koh Kawasumi , Katsumi Ishioka , Toshiro Arai and Ichiro Yamamoto
  G-protein-coupled receptors (GPRs) 40 and 120 are members of the Free Fatty Acid (FFA) receptor group and are termed FFAR1 and FFAR4, respectively. The aim of this study was to clone cat GPR40 and GPR120 cDNAs in several tissues. There was high sequence homology to other mammalian GPR40 and GPR120, with encoding 320 and 361 amino acid residues, respectively. Cat GPR40 encoded extra 21 amino acid residues in the C-terminal cytoplasmic region. Quantitative RT-PCR revealed expression of GPR40 mRNA in the duodenum, liver and pancreas. The GPR120 mRNA was expressed in adipose tissues, cerebral cortex and colon. In conclusion, GPR40 and GPR120 were well conserved and were expressed in cat tissues with different distribution patterns.
  Nobuko Mori , Koh Kawasumi , Tomoko Suzuki , Ichiro Yamamoto , Motoo Kobayashi and Toshiro Arai
  In this study, researchers attempted to establish temporary criteria for Metabolic Syndrome (MS) diagnosis in cats. To verify the usefulness of the selected criteria, we investigated changes in plasma glucose, Triglyceride (TG), Total Cholesterol (TC), Alanine Aminotransferase (ALT) insulin and adiponectin levels as diagnostic factors in 50 clinically healthy cats. Cats with obesity as an essential factor in addition to any two of the three conditions, namely increased plasma glucose levels, elevated TG and/or TC levels and higher ALT activity were diagnosed with MS. Presence of additional factors such as reduced plasma adiponectin and/or raised insulin levels, confirmed the MS diagnosis. Based on these criteria, 9 (18.0%) cats were diagnosed with MS. In these cats, the plasma glucose, TC and ALT levels were significantly higher than those in the control cats (n = 41) without MS. MS was not detected in cats with body condition score <3 and the occurrence rate of MS was the highest in 5-10 years old cats. In the MS cats, reduced plasma adiponectin levels appeared to be an essential factor that defined the early stage of the disease.
  Nobuko Mori , Koh Kawasumi and Toshiro Arai
  Plasma metabolite concentrations reflect changes in the energy metabolic and physical conditions of animals with metabolic disorders. A reduced adiponectin level in humans and rodents is the critical factor associated with the pathogenesis of obesity-associated atherosclerosis, insulin resistance and type 2 diabetes mellitus. Appropriate plasma metabolic markers appear to be useful for the early diagnosis of latent metabolic disorders with no clinical signs in animals. The aim of this study was to assess changes in the values of plasma metabolic markers in healthy ageing dogs. Significant differences were observed in the plasma insulin and total cholesterol concentrations in healthy dogs of different genders and ages. Adiponectin concentrations peaked at a young age and decreased with ageing. Apparently, insulin increased according to age. Plasma insulin concentrations were particularly influenced significantly by age as well as glucose and triglyceride levels whereas adiponectin concentrations were affected by gender on multiple linear regressions for all factors. No criteria exist for the early diagnosis of latent metabolic disorders without remarkable signs regarding age and gender in dogs. Thus, in case of dogs, it may be necessary to set up improved age-dependent criteria for metabolic disorders with changes in plasma insulin concentrations.
  Koh Kawasumi , Tomoko Suzuki , Megumi Fujiwara , Nobuko Mori , Ichiro Yamamoto and Toshiro Arai
  Researchers attempted to establish temporary criteria for Metabolic Syndrome (MS) diagnosis in dogs. To verify the usefulness of the selected criteria, researchers measured plasma Glucose (GLU), Triglyceride (TG), Total Cholesterol (TC), Non-Esterified Fatty Acid (NEFA), Alanine Aminotransferase (ALT) and insulin levels as diagnostic markers in 105 clinically healthy dogs. Dog with obesity as an essential factor (BCS = 3.5) in addition to any two of the following three factors 1-3 namely increased plasma GLU levels (≥120 mg dL-1), hyperlipidemic condition, diagnosed with any two of the following three factors, elevated TG (≥165 mg dL-1), TC (≥200 mg dL-1), NEFA (≥1.5 m Eq-1) levels and higher ALT activit (≥100 IU L-1) were diagnosed as MS. Presence of additional factors such as raised insulin levels (≥2.5 ng mL-1), confirmed the MS diagnosis. Based on these criteria, 13 (12.9%) of 101 dogs were diagnosed as MS. In these dogs, NEFA, TC and ALT levels were significantly higher than those in the control dogs (n = 88) without MS. MS was not detected in dogs with Body Condition Score (BCS)<3.
 
 
 
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