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Literature reports suggest a tremendous decline in the global incidence, mortality and morbidity of Colorectal Cancer (CRC) during the post-millennium as compared to the pre-millennium. These developments are attributed to the advancement in technicalities and researches. The status of CRC in the Kingdom of Saudi Arabia (KSA) during the pre-millennium restricted to most of the etiological, histological and epidemiological researches while progress around the world had already begun studies on molecular level. During the third millennium, there are active genome level researches in addition to the development of the link of MicroRNAs with progression of cancer. Although, research on gene expression began in KSA but its involvement in the discovery of newer compounds is still a vision. Furthermore, the researches in KSA lag behind in the new developed era of MicroRNAs. This review on the development of research activities on CRC has revealed that researches in KSA are slow and late but do not lag behind in the global scientific maneuvers taking place in the third millennium.
