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Articles by Khairul Anam
Total Records ( 3 ) for Khairul Anam
  Sukrasno Sukrasno , Irda Fidriany , Kusnandar Anggadiredja , Wafiq Auliana Handayani and Khairul Anam
  The aim of this study was to search for the optimal method to prepare crude drug with the highest flavonoid content from fresh Cosmos caudatus leaves. Flavonoid contents of Cosmos caudatus leaves were studied in relation to the processes involved in food and herbal medicine preparation. Quercitrin and rutin were identified as the major flavonoid component of the leaves. The flavonoid content substantially increased during boiling in water. This increase was not caused by the enhancement of extractability but more likely to be due to the endogenous biotransformation of precursor or intermediates into flavonoids. However, heating of fresh leaves in an air oven at elevated temperature from 30 to 100°C decreased the total flavonoid content except at 40°C by which the total flavonoid content increased approximately by 30%. Pre-heating of leaves at 60°C substantially reduced flavonoid content to only 30% compared to control and further drying at 60°C left the flavonoid to only 12% compared to control. The experiments suggested that drying temperature affects flavonoid content of Cosmos leaves and the highest content might be obtained when the leaves is prepared by drying at 40° C.
  Sukrasno , Kartika , Irda Fidrianny , Elfahmi and Khairul Anam
  Curcuma xanthorrhiza is one the most important of Indonesian crude drug. Its pharmacological activities are usually associated with curcuminoid and the essential oil content. This study was aimed at studying the influence of the crude drug preparation on the content and the composition of volatile oil Curcuma rhizome. The bulky rhizomes were stored at room temperatures and their volatile oil contents measured. The composition of the oil was analyzed by GC-MS. The rhizomes were sliced, dried, comminuted and their oil content measured. Storage of bulky rhizome at room temperature continuously decreased the yield of volatile oil from bulky fresh rhizome. Storage did not change the number and the identity of the oil component: However, it altered their composition. Germacron, xanthorrhizol and α-curcumene increased while dipi-α-cedren decreased during storage. Upon slicing, drying under the sun, drying in an air oven, grinding and storage of the dried Curcuma rhizome, most of the volatile oil was still retained in the crude drug. Storage of bulky Curcuma rhizome continuously decreased its volatile oil content and the lost of oil reach 57% after 12 weeks. It is suggested that to assure the highest level of volatile oil content in the preparation of Curcuma crude drug, the rhizome should be immediately sliced and dried after harvest.
  Khairul Anam , Dwi Susilo , Dewi Kusrini and L.N.A. Agustina
  Background and Objective: Avicennia marina is one of the mangrove species which have various properties in traditional medicine. Extracts of the leaves have anticancer and antiviral activity. Seeds have antimalarial activity. Stems and fruit used as a cure rheumatism, skin diseases and inflammatory. While, the tree exudates efficacious as contraceptives and gout medicine. Scientific support for the use of exudates in traditional medicine is relatively limited. The purpose of this study is the verification of the use of A. marina exudate as lowering uric acid levels. Materials and Methods: In this study, analyzed the content of chemical, anti-hiperurisemia activity test by inhibiting the enzyme xanthine oxidase method toward extract and fractions of A. marina exudate and identification of the primary chemical compounds in the active fraction. Results: The results showed that the A. marina exudate containing flavonoids, tannins, quinones, saponins and steroid/triterpenoid. Ethanol extract of A. marina exudate has anti-hiperurisemia activity (IC50 = 202.4 ppm) and their ethyl acetic fraction (IC50 = 0.42 ppm) had stronger activity than the total extract. Conclusion: The identification results of component in the active by UV-vis spectrometer and FTIR thought to contain 5,7,3',4' tetrahidroxyflavone (Luteolin).
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