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Articles by Khaerunissa Anbar Istiadi
Total Records ( 1 ) for Khaerunissa Anbar Istiadi
  Priscilla Ardianto , Ade Arsianti , Khaerunissa Anbar Istiadi and Fadilah Fadilah
  Background and Objective: Cervical cancer is one of the most frequently found cancers in women. Studies have demonstrated the correlation between inflammation mediated by COX-2 and cancer proliferation. This research was conducted to observe and compare the effects of different alkylated salicylic acid derivatives on the proliferation of cervical cancer HeLa cell. Materials and Methods: Alkylated salicylic acid was synthesized by reacting salicylic acid with n-alcohol through Steglich esterification. Its products’ physical and chemical properties were measured by using apparatus and by observation. The products of the reaction were analyzed by thin-layer chromatography. Alkylated derivatives of salicylic acid were tested using an MTT assay to determine their percentage inhibition and IC50 value against HeLa cell. The IC50 values were compared with the IC50 value of salicylic acid. Results: The thin layer chromatography profile for alkylated salicylic acids using non-polar eluent (n-hexane:ethyl acetate = 4:1) are methyl salicylate (Rf =0.75), ethyl salicylate (Rf = 0.78), butyl salicylate (Rf = 0.90), isoamyl salicylate (Rf = 0.95) and octyl salicylate (Rf = 0.81). The MTT result shows that both salicylic acid and its alkylated derivatives showed cytotoxic activity. Conclusion: All alkylated derivatives of salicylic acid have better anti-proliferative activity compared to salicylic acid. The length of the alkyl chain was not related to the anti-proliferative activity. Out of all alkylated salicylic acid derivatives, butyl salicylate had the best anti-proliferative activity.
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