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Articles by Kathleen M. Hayden
Total Records ( 2 ) for Kathleen M. Hayden
  Richard Mayeux , Christiane Reitz , Adam M. Brickman , Mary N. Haan , Jennifer J. Manly , M. Maria Glymour , Christopher C. Weiss , Kristine Yaffe , Laura Middleton , Hugh C. Hendrie , Lauren H. Warren , Kathleen M. Hayden , Kathleen A. Welsh- Bohmer , John C.S. Breitner and John C. Morris
  In this article, the challenges faced by several noted population studies for Alzheimer dementia in operationalizing current clinical diagnostic criteria for Alzheimer‘s disease (AD) have been reviewed. Differences in case ascertainment, methodological biases, cultural and educational influences on test performance, inclusion of special populations such as underrepresented minorities and the oldest old, and detection of the earliest symptomatic stages of underlying AD have been considered. Classification of Alzheimer dementia may be improved by the incorporation of biomarkers for AD if the sensitivity, specificity, and predictive value of the biomarkers are established and if they are appropriate for epidemiological studies, as may occur should a plasma biomarker be developed. Biomarkers for AD could also facilitate studies of the interactions of various forms of neurodegenerative disorders with cerebrovascular disease, resulting in ”mixed dementia“.
  Kathleen M. Hayden , Jill M. McEvoy , Colton Linnertz , Deborah Attix , Maragatha Kuchibhatla , Ann M. Saunders , Ann M. Saunders , Kathleen A. Welsh- Bohmer , Allen D. Roses and Ornit Chiba- Falek
  Introduction A highly polymorphic T homopolymer was recently found to be associated with late-onset Alzheimer‘s disease risk and age of onset. Objective To explore the effects of the polymorphic polyT tract (rs10524523, referred as ’523‘) on cognitive performance in cognitively healthy elderly individuals. Methods One hundred eighty-one participants were recruited from local independent-living retirement communities. Informed consent was obtained, and participants completed demographic questionnaires, a conventional paper-and-pencil neuropsychological battery, and the computerized Cambridge Neuropsychological Test Automated Battery (CANTAB). Saliva samples were collected for determination of the TOMM40 ’523‘ (S, L, VL) and the apolipoprotein E (APOE) (ɛ2, 3, 4) genotypes. From the initial sample of 181 individuals, 127 were eligible for the association analysis. Participants were divided into three groups based on ’523‘ genotypes (S/S, S/L-S/VL, and L/L-L/VL-VL/VL). Generalized linear models were used to evaluate the association between the ’523‘ genotypes and neuropsychological test performance. Analyses were adjusted for age, sex, education, depression, and APOE ɛ4 status. A planned subanalysis was undertaken to evaluate the association between ’523‘ genotypes and test performance in a sample restricted to APOE ɛ3 homozygotes. Results The S homozygotes performed better, although not significantly, than the S/L-S/VL and the VL/L-L/VL-VL/VL genotype groups on measures associated with memory (CANTAB Paired Associates Learning, Verbal Recognition Memory free recall) and executive function (CANTAB measures of Intra-Extra Dimensional Set Shift). Follow-up analysis of APOE ɛ3 homozygotes only showed that the S/S group performed significantly better than the S/VL group on measures of episodic memory (CANTAB Paired Associates Learning and Verbal Recognition Memory free recall), attention (CANTAB Rapid Visual Information Processing latency), and executive function (Digit Symbol Substitution). The S/S group performed marginally better than the VL/VL group on Intra-Extra Dimensional Set Shift. None of the associations remained significant after applying a Bonferroni correction for multiple testing. Conclusions Results suggest important APOE-independent associations between the TOMM40 ’523‘ polymorphism and specific cognitive domains of memory and executive control that are preferentially affected in early-stage Alzheimer‘s disease.
 
 
 
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