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Articles by Karem Aly Fouda
Total Records ( 3 ) for Karem Aly Fouda
  Ahmed M. S. Hussein , Karem Aly Fouda , Ahmed Noah Badr and Adel G. Abdel-Razek
  Background and Objective: Aflatoxin B1 (AFB1), a pre-carcinogenic and toxic compound which contaminates foodstuffs and edible tissues, is associated with oxidative stress and hepatotoxicity. This investigation aimed to assess the counteractive role of ethanol (EWP), petroleum ether (PWP) and n-hexane (HWP) white pepper extracts for oxidative stress and hepatotoxicity induced by AFB1 in a rat model. Materials and Methods: Concentrated white pepper extracts (WPEs) estimated for total phenolic, total flavonoids, anti-oxidant and anti-fungal activities. Otherwise, the fatty acids composition of white pepper was analyzed. Forty-eight male albino rats were divided into 8 groups, negative and positive AFB1 groups and the other 6 groups were treated to evaluate the WPEs biological effects either in the AFB1 presence or absence. Results: The results elucidated that WPEs suppressed both the raising of aminotransferases enzymes (alanine and aspartate) and alkaline phosphatase and the reduction of total protein. The WPEs combat the negative impact of AFB1 on kidney functions and alleviated AFB1 mediated oxidative stress either in plasma or liver. Also, it relieved the AFB1 mediated lipid disturbance and hemoglobin reduction and exhibited antioxidant and antifungal activities. Conclusion: It was concluded that the extracts gave a counteractive role for oxidative stress which support the hepatotoxicity induced by AFB1 presence.
  Doha Abdou Mohamed , Ibrahim Mohamed Hamed and Karem Aly Fouda
  Background and Objective: Diabetes is a metabolic disease associated with hyperglycemia. Diabetes is the major cause of morbidity and mortality worldwide. Chronic hyperglycemia in diabetic patients leads to damage and dysfunction of many organs. The aim of the present research was studying the anti-diabetic potential of crude ethanol extract of cumin seeds (CEEC). Methods: CEEC was prepared. Diabetes was induced in rats by single dose of streptozotocin (STZ). Total flavonoids and total phenolic contents were determined in the CEEC. Free radical scavenging activity of the extract was estimated using DPPH method. Acute toxicity of the CEEC on mice was determined. The effect of CEEC on glucose tolerance was evaluated. Results: The results revealed that total phenolic and total flavonoids were presence in the CEEC by 23.02±0.045 mg GAE g–1 extract and 19±0.132 mg QE g–1 extract, respectively. CEEC showed free radical scavenging activity. Acute toxicity revealed that CEEC was completely safe up to 12 g kg–1 mice. Oral administration of CEEC reduced glycemic levels. CEEC significantly reduced plasma glucose levels in diabetic rats and elevate insulin levels significantly compared with diabetic control. CEEC improved plasma lipid profile, reduced oxidative stress and reduced inflammation in diabetic rats. Conclusion: Crude ethanol extract of cumin seeds may be used as alternative treatment for diabetes. The results indicated that CEEC may be very helpful in the improvement of plasma lipid profile as one of the risk factors for cardiovascular diseases and heart failure in diabetic patients.
  Ahmed M.S. Hussein , Mona M. Hussein , Manal F. Salama , Ibrahim M. Hamed , Karem Aly Fouda and Rasha S. Mohamed
  Background and Objective: School children especially in Egypt need a safe meal which is able to meet their daily nutrient needs and ameliorate cognition. So, the current study aimed to evaluate formula prepared as cookies to be served as a meal for primary school children. Materials and Methods: Wheat, roasted chickpea, milk protein concentrate, cinnamon and brewer's yeast were used to prepare cookies which have been exposed to sensory, chemical and biological evaluation. Peroxide number, amino acids, vitamins (D, B12, folic acid and E) and minerals (calcium, zinc, iron and selenium) were determined. Twenty four rats of weaning age were used, 12 rats to estimate the true protein digestibility and 12 rats to estimate the protein efficiency ratio and the effect of feeding on cookies (28 days) on hemoglobin, glucose, total protein, liver and kidney functions and antioxidant status. Results: Palatability and acceptability of cookies were insured via the sensory evaluation results. The value of peroxide number indicated that there is no possibility of rancidity during the storage. The cookies showed high contents of protein (14.88%), fat (16.83%) and carbohydrate (55.1%). Also cookies showed acceptable levels of amino acids, minerals and vitamins that meet a large amount of daily requirements of children. Results of the animal experiment declared the complete safety of the cookies and high nutritional and biological quality. Conclusion: Cookies can serve as a meal for the governmental school children to provide them with their needs from nutrients that reducing hunger and improving health benefits and scholastic achievement.
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