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Articles by Kamran Kaveh
Total Records ( 9 ) for Kamran Kaveh
  Kamran Kaveh , Rashid Ibrahim , Mohd Zuki AbuBakar and Tengku Azmi Ibrahim
  Problem statement: Osteoporosis; the major health problem is an imperative disease requires a significant attention to discover different aspects of this threatening abnormality. There are some problems in osteoporotic human population to conduct researches such as lack of a homogenous sample size or ethical problems. So, there was a need to have protocol in animal model to let the scientists discover various feature of this disease to promote health status of the human population. The aim of this research was to make such protocol in animal model. Approach: About 15 rabbits were utilized in the current research. Six animals of Group 1 have undergone bilateral ovariectomy which was followed by IM injection of 1 mg kg-1 day of methylprednisolone. Six rabbits of second group only undergone bilateral ovariectomy and three animal of Group 3 served as a control group. They neither undergone any surgery nor received any medications. After surgery up to four weeks radiographs were taken. At week four animals were euthanized and samples of cortical and chancellors’ bone were evaluated by light and scanning electron microscopes. Results: Group 1 completely manifested features of osteoporotic bone. Complete radiolucent view with cortical thinning in radiographs as well as broken, thinned and perforated chancellors bone trabecullae in light and electron microscope confirmed the osteoporotic nature of both cortical and chancellors’ bone. Ovariectomy alone did not show sufficient potential to induce osteoporosis in rabbits in such short period. Conclusion: As the conclusion, bilateral ovariectomy following injection of mild doses of glucocorticoids could result in a fast, easy and trustable protocol to induce osteoporosis in rabbit model. This procedure could be utilized in creating osteoporotic rabbits for better understanding of unknown aspects of the recent growing syndrome.
  Kamran Kaveh , Rashid Ibrahim , Mohd Zuki Abu Bakar and Tengku Azmi Ibrahim
  The main aim of the present study was to investigate, the effect of combination of bone marrow as the primary origin of osteoblast and at the same time as the seed cell and corticocancellous bone graft as the natural scaffold in the repair of critical sized defect compact bone in rabbit. For the test group, bone marrow has been aspirated and seeded into the corticocancellous bone graft, which was used to repair critical size bone defect made in mid shaft femoral bone of the same rabbit. Corticocancellous bone graft itself was utilized as the control group. Radiographs were taken to observe the healing during the 8 weeks of study period. Rabbits were euthanized after 8 weeks. The femoral bone was removed for gross observation, histopathological and scanning electron microscope assessment and evaluation. New bone formation and osteogenesis was observed at the margins and centre of the test group. The bone formation pattern included osteogenesis, osteoinduction and osteocunduction. In the implant of only corticocancellous autograft bone, the major new bone formation was at the margins of the defect and osteogenesis was not observed at the centre of the defect. The combination of bone marrow and corticocancellous bone autograft had better results than corticocancellous bone graft alone in osteogenesis. Bone formation capability and critical sized defect repair was faster in the test defect.
  Mozhdeh Emadi , Fatemeh Jahanshiri , Kamran Kaveh , Mohd Hair-Bejo , Aini Ideris and Razak Alimon
  Infectious bursal disease is still a challenging issue by posing a serious threat to the commercial poultry industry especially due to the emergence of highly Infectious Bursal Disease Virus (IBDV). In the present study, we evaluated the immunomodulatory effects of Tryptophan (Trp) on innate, humoral and cellular immune responses in chickens challenged by oral administration of intermediate plus strain of IBD virus at 28 days of age. A corn-soybean meal based diet containing different levels of Trp (0, 0.10 and 0.20) for the starter, (0, 0.07 and 0.15) for the grower and (0, 0.05 and 0.13) for the finisher has been utilized. In a completely randomized design with three treatments of five replicates each and 10 chickens per replicate, 150 Cobb 500 male broiler chickens from 0-49 days of age were subjected to Trp diet. To measure the innate, cellular and humoral immunity indicators (interferon-α, interferon-γ, immunoglobulin G, respectively) at 27, 35, 42 and 49 days of age, serum samples from each replicate of treatments were collected and subjected to ELISA. The result showed that Trp supplementation in the chickens basal diets significantly increased the serum levels of interferon-α at 35, 42 and 49 days of age (p<0.05), interferon-γ at 27, 35 and 49 days of age (p<0.05) and immunoglobulin G at 27, 35, 42 and 49 days of age (p<0.05). These results strongly suggest that tryptophan plays a vital role in modulation of protective immune response against IBDV.
  Mozhdeh Emadi , Kamran Kaveh , Fatemeh Jahanshiri , Mohd Hair-Bejo , Aini Ideris and Abdul Razak Alimon
  In order to study the effect of Tryptophan (Trp) on growth performance and blood parameters of broiler chickens, an in vivo experiment was conducted. A corn-soybean meal based diet containing different levels of Trp (0, 0.10 and 0.20) for the starter, (0, 0.07 and 0.15) for the grower and (0, 0.05 and 0.13) for the finisher was used. In a completely randomized design with three treatments of five replicates each and 10 chickens per replicate, 150 Cobb500 male broiler chickens from 0-49 days of age were subjected to Trp diet. Growth performance (body weight gain, feed intake and feed, gain ratio) and blood serum (albumin, total protein, glucose, cholesterol, triglyceride, urea, uric acid, aspartate amino-transferase, alanine amino-transferase, alkalin phosphatase, lactic dehydrogenase and creatine kinase) parameters were measured at 27 and 49 days of age. As the result showed the increase of dietary Trp elevated (p<0.05) body weight gain, feed intake, albumin, total protein, glucose, urea and uric acid and decreased (p>0.05) feed gain ratio, aspartate amino-transferase, lactic dehydrogenase, triglyceride and cholesterol. Therefore, we conclude that dietary Trp might have positive effects on health status of the broiler chickens.
  Kamran Kaveh , Rashid Ibrahim , Mozhdeh Emadi , Mohd Zuki Abu Bakar and Tengku Azmi Ibrahim
  Osteoporosis is a metabolic bone disorder, which is characterized by a decreased in the overall amount of bone mass. This is major public problem with 30% mortality rate within the first year following osteoporotic hip fracture. The altered microarchitectural structure of bone would lead to increased susceptibility to fractures. By improving the public health and aging of the population, the incidence of this disorder is also increasing. Different treatments costs of patients is showing an increasing trend, which implies that there should be a public education regarding this threatening abnormality. Prevention rather than treatment has to be publicized by correct instructing the population and especially in the women society. This review has a brief simple but concise outlook at osteoporosis its manifestation, treatment and prevention.
  Kamran Kaveh , Rashid Ibrahim , Mohd Zuki Abu Bakar and Tengku Azmi Ibrahim
  Restoring skeletal integrity and bone tissue regeneration is still a significant challenging issue. In this regard, bone grafting have been used to augment orthopedic repairs in human and veterinary surgery for several decades and still being under many investigation to hunt for new approaches to improve bone healing following incidences of bone complications. Bone graft is bone transplant and is categorized into autogenous and allogenic grafts as well as synthetic bone graft which are bone graft substitutes. Each of these classified grafts have some advantageous as well as a range of drawbacks, which researchers are still looking to remove those disadvantageous. Finding new instruments and new sites for graft harvests are the major concerns of researchers to diminish the morbidities of donor site in autografts. Looking for agents boosting inductivity of the allografts is the main worries of these kinds of grafting materials and finally new fabrication techniques by new pore sizes are the significant bothering for synthetic bone graft substitutes. This review would consider all grafting methods and materials that would open new windows to the bone grafting techniques.
  Kamran Kaveh , Rashid Ibrahim , Tengku Azmi Ibrahim and Mohd Zuki Abu Bakar
  The main aim of the present study was to investigate the effect of combination of bone marrow as the primary origin of osteoblast and at the same time as the seed cell and corticocancellous bone graft as the natural scaffold in repair of compact bone full thickness segmental critical sized defect in rabbits. Twelve rabbits had been divided into two groups; In Group one, fresh autogenous bone marrow aspirate has been seeded into the scaffold of autogenous corticocancellous bone graft which was utilized to repair critical size compact bone defect in mid shaft of radius. Corticocancellous bone graft alone was used as the Group 2 or control group. Up to 8 weeks, radiographs were taken to evaluate the level of osteogenicity in both groups. Rabbits were euthanized on week eight postoperative and the implants were harvested for gross, histological and scanning electron microscope observations. New bone formation and osteogenesis was observed at the margins and centre of the Group 1. Combination of mature and immature trabecullae covered the defect and bone formation pattern included osteogenesis, osteoinduction and osteocunduction. In the implant of corticocancellous bone graft alone or group 2, the major new bone formation was at the margins of the defect and osteogenesis was not observed at the centre of the defect and the major bone formation pattern was creeping substitution. As the conclusion, combination of bone marrow and corticocancellous bone graft had better results than corticocancellous bone graft alone in osteogenesis potential. Bone formation capability and critical sized defect repair was faster and more efficient and successful in Group 2 defect.
  Kamran Kaveh , Md. Zuki Abu Bakar , Behrang Ekrami , Hamid Ghasemzadeh-Nava , Parviz Tajik , Mahmood Bolourchi and Amin Tamadon
  Aim of the current study was to evaluate the effect of Flunixin Meglumine (FM) post insemination injection on Corpus Luteum (CL) function, its Progesterone (P4) secretion and pregnancy rate of dairy cows in heat stress condition. Estrus cycles of 120 Holstein cows were synchronized utilizing ovsynch protocol and cows were artificially inseminated. Environmental data indicated that the cows experienced medium heat stress during trials (mean daily temperature-humidity index = 79-84). They were randomly divided into three equal groups of 40. Two groups received FM injection between days 2-5 and 10-13 post inseminations once daily and the third group was selected as control. Blood samples were collected on days 7 and 14 post insemination for analysis of plasma P4 concentrations. Ultrasonography scanning was performed on these days for CL detection following which its volume was calculated. The pregnancy status of the cows was estimated at days 27-30 by ultrasonography and confirmed on day 42 by palpation per rectum. Plasma P4 concentrations showed no significant difference in groups receiving treatment compared by the control (p>0.05). However, CL volume was different between the treated groups on day 14 (p = 0.03). The pregnancy rate in group FM 10-13 (20%) was higher than that of group FM 2-5 (17.5%) and control (15%) but this improvement was not statistically significant (p>0.05). Treatment of heat stressed dairy cows with FM post insemination between days 2-5 or 10-13 led to CL maintenance but this treatment could neither increase the serum P4 concentrations nor improve the pregnancy rate.

  Kamran Kaveh , Rashid Ibrahim , Md. Zuki Abu Bakar and Tengku Azmi Ibrahim
  Mesenchymal Stem Cells (MSC) are multipotent non-hematopoietic progenitor cells with an extensive proliferation potential and ability to differentiate into various cell types including osteoblasts, chondroblasts, myocytes, adipocytes and neurocytes. MSC is a cell of bone marrow population that plays a key role in bone marrow homeostasis and regulates the maturation of both hematopoietic and non-hematopoietic cells. Mesenchymal stem cells have been emerged in promising therapeutic modality for tissue regeneration and repair. Treatment of graft versus host disease, heart regeneration following infarction, cartilage and bone repair and treatment of osteogenesis imperfecta are only few therapeutic application of MSC. Tissue engineering in recent years opened a new frontier to replace the affected tissue by MSC assistance. Mesenchymal stem cell seems to be the future powerful tool in therapeutic application of regenerative medicine in repairing and replacing the impaired organs. The main aim of current review is to have a more precise look to MSC, its proliferation and differentiation potentials, therapeutic application and bone tissue engineering.
 
 
 
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