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Articles by Kamil SEYREK
Total Records ( 2 ) for Kamil SEYREK
  Hasan Aksit , Kamil Seyrek , Funda Kiral , Pinar Alkim Ulutas and Turgut Sekerler
  Diabetes is an increasing worldwide health problem. It is well known that diabetes causes brain damage. The mechanism by which diabetes increases brain damage is still elusive. The objective of this study was to determine the effects of streptozotocin-induced diabetes on rat brain tissue. Twenty rats were divided into control and experimental groups at random. In experimental animals diabetes was induced by intraperitoneal injection of a single 50 mg kg-1 dose of streptozotocin while the animals in control group received sodium citrat buffer. Induction of diabetes with streptozotocin resulted in a statistically significant increase in the glucose and malondialdehyde levels whereas ascorbic acid concentrations and Total Antioxidant Status (TAS) decreased significantly in these animals. Compared to the control animals hyperglycemia induced apoptosis in brain tissue of experimental rats significantly. In conclusion, in streptozotocin induced hyperglycaemia in diabetic rats leads to oxidative stress and induce apoptosis in brain tissue. In addition, increased rate of apoptosis might be due to elevated concentrations of reactive oxygen species.
  Kamil SEYREK , Hakan ERBAS , Mukadder SERTER , Cigdem YENISEY , Funda KIRAL and Husnu Erbay BARDAKCIOGLU
  A considerable body of data exists regarding the role of vitamin C in mammalian physiology; however, there are no data about the effects of dietary ascorbic acid supplementation on collagen concentrations and amino acid levels in animals exposed to heat stress. The present study investigated the effects of supplementary ascorbic acid intake on collagen concentrations in the brain and heart tissue in Japanese quails. In addition, glycine, glutamine, histidine, asparagine, and serine contents in the livers of the same animals were measured. Japanese quails were allocated into 4 groups, each of which was exposed to heat stress (34.8 ± 1.25 °C) for 75 days. Control animals were fed a basal diet, while animals in the experimental groups were fed a basal diet supplemented with 150, 250, or 500 mg of L-ascorbic acid kg-1 of diet. Compared to the control group, mean collagen concentration in brain tissue significantly (P < 0.05) increased only in Japanese quails given 250 mg of L-ascorbic kg-1 of diet. On the other hand, heart tissue collagen content in the quails fed vitamin C did not significantly increase; in fact, the collagen content in the group fed 500 mg of L-ascorbic acid kg-1 of diet significantly decreased (P < 0.01). Amino acid content in the liver significantly increased in the group fed 150 mg of L-ascorbic acid kg-1 of diet (P < 0.01 for serine and P < 0.001 for the others).
In conclusion, vitamin C had profound effects on collagen synthesis and amino acid metabolism in Japanese quails subjected to heat stress. Results of the present study also indicate that addition of high-dose dietary vitamin C-higher than 250 mg kg-1 of diet-may have detrimental effects in quails exposed to heat stress.
 
 
 
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