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Articles by Kamal Mansi
Total Records ( 11 ) for Kamal Mansi
  Ahmad Bani Ata , Kamal Mansi and Talal Aburjai
  This study was carried out to assess the lipid pattern in gymnasts of the Jordan National Team. Twelve athletes represent the National gymnastic team (4 males and 8 females, mean age 18±1 year) were included in this study. The training period for them is not less eight years during which they trained 18 hours weekly at least. A group of healthy males and females matched for age and gender was included as control group (n = 20). No subject had evidences of cardiovascular disease, diabetes and blood pressure .The body mass index (BMI) of the females was significantly (p<0.5) lower than that of the control (22.5±3.21, 18.9±0.9 respectively). It was found that the majority of the males had lower total cholesterol, triglycerides, and great decreasing in LDL cholesterol and significantly (p<0.5) raising in HDL cholesterol, (164.3±19.8, 85.9±34.3, 49.8±6.5, 80.4±30.8 respectively) comparing to the control group (186.6±20.7, 171.6±34.3, 44.5±5.7, 127.2±18.2 respectively). In females a similar fashion of lipid profile was also found with a great reduction in LDL-C level .Our result suggest that gymnastics exercise affect blood cholesterol and other lipids in a positive way, by regulating the metabolism of all lipids in the blood and increasing fat oxidation during training results in an adaptive mechanism for body weight maintenance. Also increasing HDL-C level in males and females gymnasts has protective value against cardiovascular diseases such as ischemic stroke and myocardial infarction by carrying cholesterol from the body's tissues and remove cholesterol from atheroma withinarteries and transport it back to the liver for excretion or re-utilization.
  Fawzi Irshaid and Kamal Mansi
  Problem statement: Urtica pilulifera L. (Urticaceae), has long been used for the treatment of various aliments including diabetes. Diabetes is a metabolic disorder characterized by hyperglycemia which has a deleterious effect on all systems including reproductive system of animals. Therefore, the current study was designed to investigate the effects of Urtica pilulifera on the reproductive system of diabetic rats. Approach: Forty male rats were evenly divided into four groups: Group I consisted of non-diabetic rats that received only the vehicle; group II-IV was injected intraperitonially with a single dose of streptozotocin (STZ) of 70 mg kg-1; groups III and IV were given methanol extract of Urtica pilulifera orally, 3 days after the STZ injection, at daily doses of 1.0 and 2.0 g kg-1, respectively. After 4 weeks of treatments, all the rats were sacrificed. Results: Administration of 70 mg kg-1 of streptozotocin to male rats induced diabetes and significantly reduced the body and sex organ weights, testosterone levels, sperm count and motility and significantly increased the glucose levels and water and food intake. By contrast, rats given the Uritica pilulifera methanol extract had significantly improved body weight gain, whereas the glucose levels, water and food intake significantly improved in treated diabetic male rats. In addition, this extract improved the reproductive system of the diabetic male rats by significantly increasing the testis and epididymis weights, testosterone levels, sperm count and motility. Conclusion/Recommendations: We concluded that the adverse effects of STZ-diabetes on reproductive system of male rats can be reversed by treatment with Urtica pilulifera leaf extract; and this leaf extract exhibits antihyperglycemic and spermatogenic activities. Based on these findings, we suggested the possible utilization of Urtica pilulifera extracted as a therapy to prevent the development of diabetes in later life and improved the performance of male reproductive system in animals and humans.
  Kamal Mansi , Ahmad Bani Ata and Khalid Al-Mosud
  One of the important effects of exercise on human body is on the metabolic system especially on lipids elevated lipids and lipoprotein are risk factors for coronary heart disease. This study was conducted to evaluate the lipid profile among Jordanian top athletes according to gender. The sample included top athletes (males and females) participated in different national teams. One hundred twenty eight Jordanian top athletes 67 males and 61 females, mean age 18.6±1 years with training experience at least 5 years and with a minimal training load of twenty training hours per week participated in competitive different sports (aerobic, anaerobic and aerobic-anaerobic) were included in this study. Group of healthy male and female (control group), matched for age and gender was also included (n = 90). No subject revealed evidences of cardiovascular disease, diabetes (fasting glucose <7 mmol L-1) or hypertension (blood pressure <130/80 mm Hg) when tested by specialized physicians. The lipid pattern included cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol. The results showed n significant differences appeared between the males and females in control, aerobic and anaerobic groups over the lipid profile variables except for triglycerides but significant differences p>0.05 appeared between the males and females groups in the aerobic-anaerobic group over the HDL-C and LDL. Researchers concluded that the most abnormalities observed on routine biochemical screening in male and female athletes are no clinical significance.
  Ziad Ermili , Kamal Mansi , Talal Aburjai , Ahmad Bani Ata and Ziad M. Hawamdeh
  Owing to considerable physical, endocrinological and metabolic adaptations, the analysis of biochemical data in elite and top-class athletes requires caution. With the aim to identify metabolic and biochemical adaptations to particular lifestyle conditions such as regular and strenuous physical exercise researchers measured the concentration of liver enzymes, bilirubin and serum albumin in Jordanian top athletes. A healthy liver is essential to optimum performance by athletes. Good liver function is required to burn fat, build muscle and provide energy. Sixty Jordanian first class athletes (34 males and 26 females, mean age 19.8±2 years with training experience of at least 5 years and with a minimal training load of 18 training hours per week participated in competitive different sports chosen in the study. Group of healthy male and female (control group), matched for age and gender was also included (n = 60). No subject revealed evidences of cardiovascular disease, diabetes (fasting glucose <7 mmol L-1) or hypertension (blood pressure <130/80 mm Hg) when tested by specialized physicians. The levels of AST, ALT and ALP for evaluation the liver functions in athletes in different groups were measured 15-18 h rest and 12 h fasting using commercial analytical kits. The results showed a significant differences (p<0.5) were observed between experimental and control group for AST (34.18±13.23 and 26.19±7.42 U L-1, respectively) for ALT (28.47±8.43 and 17.38±10.83 U L-1, respectively) and for ALP (127.85±67.54 and 83.49±19.45 U L-1, respectively). The concentration of serum albumin was decreased in athletes but the difference did not reach statistical significance (controls: 4.82± 0.37 g L-1; athletes: 4.72±0.27 g L-1). No effect of endurance exercise on serum bilirubin in healthy athletes. Researchers concluded that the most abnormalities observed on routine biochemical screening in elite Jordanian athletes are of no clinical significance.
  Kamal Mansi , Masalmeh Amneh and Hamzah Nasr
  The present study was designed to evaluate the antidiabetic and hypolipidemic effects of aqueous extract of Artemisia sieberi aerial part in normal and alloxan diabetic rats. Forty male Wister rats with body weight of 180-200 g divided into four groups two control and two experimental groups: Group 1-injected with physiological saline, group 2-received orally water extract of Artemisia sieberi (39 g kg-1 b.wt.) and served as control. Groups 3 and 4 including diabetic rats, group 3 received 10 mL kg-1 tap water and served as control and group 5 given orally water extract of Artemisia sieberi (0.39 g kg-1 b.wt.). At the end of the experimental period (14 days), animals in all four groups were fasted for 12 h and blood samples were taken for the determination of serum glucose total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol and total cholesterol/HDL cholesterol (TC/HDL-C). The treatment was given for 2 weeks. After the treatment a significant reduction was observed in fasting serum glucose levels in the treated diabetic's rats. Artemisia sieberi treatment showed considerable lowering of serum total cholesterol, triglycerides, LDL cholesterol, TC/HDL-C and an increase in HDL cholesterol in the treated diabetic group. These results suggest that the oral administration of Artemisia sieberi aqueous extract of the aerial part possesses antidiabetic and hypolipidemic effects in alloxan-induced diabetic rats.
  Kamal Mansi and Masalmeh Amneh
  This study design to evaluate the effect of Ramadan fasting on serum levels of some hormones among Jordanian healthy male students. The subjects of present study were 42 healthy Jordanian male students who fasted during Ramadan. Their mean age was 21±1.6 years. We evaluated some anthropometric parameters as body weight (kg), pulse rate (per min) and systolic and diastolic blood pressure (mmHg). All parameters at forth week of Ramadan were significantly lower than pre-Ramadan values. We evaluated blood glucose, triglycerides (TG), cholesterol, low-density lipoprotein LDL) and high-density lipoprotein (HDL) and Triglycerides at 1 day before, at week 1, 2 and 4 of the Ramadan month. It was found that high-density lipoprotein (HDL) cholesterol increased significantly during Ramadan, which indicated positive association with pulse rate and fat intake and negative association with systolic blood pressure and weight. The LDLc was significantly reduced at the end of fasting. A reduction in the average TC value was observed at the end of fasting but the difference was not statistically and there no significant rise in the TG and blood sugar values at the end of fasting. This study indicated that Ramadan fasting led to a decrease weight, LDLc significantly and significant not statistically reduction in the average TC value and significantly increasing in HDLc was noted during Ramadan. There was a non-significant rise in the TG and blood sugar value at the end of fasting. We measured blood hormone levels of testosterone luteinizing hormone (LH), follicle-stimulating hormone (FSH) and thyroid hormones (T3, T4) in all subjects of our study who were fasting for ≥12 h during Ramadan. Testosterone level was lower, significantly so for the second and fourth week of the month (p<0.05); FSH was increased, significantly for the fourth week (p<0.05); LH did not change significantly. There were no significant changes in T3 after Ramadan fasting. Short fasting is not probably accompanied by significant changes in thyroid hormone, but the repetitiveness of this in Ramadan fasting mild decrease in T4 level.
  Fawzi Irshaid and Kamal Mansi
  This research was carried out to examine the effects of methanol leaf extract of U. pilulifera on some hematological and biochemical parameters in diabetic rats. Forty rats weighting 150-185 g were divided into four groups: group I treated with a vehicle (control); group II including diabetic rats treated with a vehicle; groups III and VI including diabetic rats treated with 1.0 and 2.0 g kg-1 of the extract for 3 weeks, respectively. Rats were made diabetic by injection with a single dose of streptozotocin (70 mg kg-1, i.p). At the end of the experimental period, rats were killed and blood samples were taken for biological analysis. The blood glucose level, Erythrocyte Sedimentation Rats (ESR), Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), urea and creatinine levels significantly increased in diabetic rats as compared to control. By contrast, significant reduction of the erythrocyte and leukocytes counts and Pack Cell Volume (PCV), Thyroxine (T4) and Triiodothyronine (T3) and Thyroid Stimulating Hormone (TSH) levels in diabetic group were also noticed in diabetic rats as compared to control. Treatment of diabetic rats with this extract caused a significant decrease in blood glucose levels, ESR, urea and creatinine, whereas ALT and AST slightly lowered. In addition, in diabetic treated groups, the erythrocyte and leukocyte counts and PCV, T3, T4 and TSH values significantly increased, whereas the leukocyte count slightly increased. We can concluded that U. pilulifera extract improves the diabetic status in terms of blood sugar and alleviates the diabetes-induced disturbances of some hematological and biochemical parameters of rats.
  Ahmad Baniata , Kamal Mansi , Talal Aburjai and Suha Adeeb
  Our main objective in this study is to assess the relationship between the serum levels of vitamin B12 and balance time and balance frequency among Jordanian top athletes. For this purpose, Force Platform, model (1603 stability) is used. The study group consists of 119 Jordanian top athletes, 67 males and 52 females, mean age 18.6±1 year, with training experience at least 5 years and with a minimal training load of 20 training h/week participated in different competitive sports (aerobic, aerobic-anaerobic and anaerobic). A group of healthy 35 male and 46 female adolescents (control group), matched for age and gender was also, included (n = 81). Significant differences (p<0.05) between experimental and control groups were detected for vitamin B12 (379.79±141.89, 148.81±23.83 pg mL-1, respectively), balance time (16.68±6.28, 8.96±0.57, respectively) and balance frequency (4.94±4.16, 7.59±4.16, respectively). No significant differences (p>0.05) were observed for the measured variables between males and females in the experimental group. Females have shown higher values both in vitamin B12 and balance frequency compared to males in the control group. Sheffe post hoc test and correlation values did not show any statistical difference between the levels of vitamin B12 from one side and balance time and balance frequency from the other side. We conclude that the Jordanian top athletes have higher values of B12 compared to none athletes, without any effects on the balance time and balance frequency.
  Kamal Mansi , Saif Altamemi , Sami Aloush and Mohammed Albashtawy
  The purpose of this study was to assess the effect of haemodialysis on thyroxin level in patients with chronic renal failure. The sample of this study included forty nine participants (28 male and 21 female). Eligible participants were patients on regular dialysis for >1 year at the time of enrollment, had no co morbidity and had no known previous thyroid dysfunction. The study was conducted in one educational hospital in Jordan. Serum level of thyroid hormones T4 and T3 were measured prior to the dialysis session and after completion. There was a statistically significant increase in the level of T3 and T4 after completion of dialysis, however, this increase did not go beyond the normal value. Haemodialysis initiate a trend for increase in the level of thyroxin hormones. Patients on chronic dialysis need vigilant assessment for thyroid function in order to prevent future complications.
  Kamal Mansi , Talal Aburjai and Mohammed Albashtawy
  Thalassemia is one of the systematical diseases that occur worldwide and is the commonest form of hemoglobinopathy in Jordan. The most important cause of mortality and morbidity in these patients with thalassemia is organ failure related with the shortened red cell life span, rapid iron turnover and tissue deposition of excess iron. These are the major factors responsible for functional and physiological abnormalities found in various forms of thalassemia. The aim of this research was to examine the biochemical factors related to kidney functions such as glucose, urea, creatinine, sodium and potassium levels among Jordanian children with β-thalassemia major treated with deferoxamine. Forty two patients (aged 12-28 years) with β-thalassemia major (20 males and 22 females) that undergo periodical blood transfusion and they are on Deferoxamine (DFO) as chelating agent were involved in this study. All patients were free from HBV, HCV and HIV. The diagnoses of β-thalassemia major were made based on the clinical, hematological and hemoglobin electrophoresis profiles for the patients. Hb electrophoresis for the father and mother and genetic study of the b globins genes in some disputable cases were also done. Forty controls of matched age and gender (20 males and 20 females) were also included in this study. Results showed that the significant differences (p<0.05) appeared between the experimental and control groups over all the physiological variables measured (urea, creatinine, uric acid, sodium and potassium) except for blood glucose and chloride. Researchers conclude that the functional abnormalities of the kidney in patients with β-thalassemic patients can be attributed to chronic anemia, iron overload as well as to (DFO) toxicity and enhancement the oxidative stress induced by excess iron deposits. These functional abnormalities would have any long-term effects on the patients.
  Kamal Mansi , Maryam Abu-Albasal and Talal Aburjia
  Hepatoprotective effect of methanolic extracts from Artemisia sieberi Besser aerial parts was investigated against ethanol induced-acute hepatotoxicity in experimental rats. They were divided into four groups with 20 rats in each one. Group I: non-hepatotoxic rats received only the vehicle (0.5 mLkg-1 body weight) and served as a control group. Group II: rats were orally administered with 2 mL ethanol every alternate day for 30 days to generate hepatotoxity. Groups III: hepatotoxic rats treated with 25 mgkg-1 silymarin drug. Group IV: hepatotoxic rats treated with 100 mgkg-1 methanol extracts of Artemisia sieberi Besser. All treatments were orally administrated by gavage for 30 consecutive days. At the end of the experiment, the rats of all groups were sacrificed and the excised liver was weighed. Liver enzyme markers (SGOT, SGPT, ALP), total protein, albumin, bilirubin (direct and total) and lipid profile were measured from blood serum samples. As well, the analysis of the CBC was performed on whole blood samples. Results revealed significant increase of the liver enzyme markers, total and direct bilirubin and lipid profile in the hepatotoxic group. Conversely, significant reduction in the liver weight, levels of total protein, albumin and parameters of the CBC panel was also noticed as compared with the control group. However, treatment with methanol extracts significantly enhanced the liver weight and brought back the altered levels of hematological and biochemical markers to the nearby normal levels, compared to those detected in the control and silymarin treated groups. It is concluded from the results of the present study that the methanol extracts of Artemisia sieberi Besser aerial parts possesses hepatoprotective activity against ethanol induced hepatotoxicity in rats.
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