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Articles by K.V. Pugalendi
Total Records ( 2 ) for K.V. Pugalendi
  M. Sridevi , G. Chandramohan and K.V. Pugalendi
  In this study, the protective effect of alcoholic leaf extract of Solanum surattense on blood glucose and redox status in streptozotocin (STZ)-induced diabetic rats has been evaluated. Diabetes was induced in adult male albino Wistar rats weighing 180-200 g, by the administration of STZ (40 mg kg-1 body weight) intraperitoneally. The diabetic rats showed elevated levels of blood glucose and a significant decrease in plasma insulin levels. The increased levels of lipid peroxidation markers such as thiobarbituric acid reactive substances (TBARS), conjugated dienes (CD) and lipid hydroperoxides (LOOH) were observed in diabetic rats. The activities of enzymatic antioxidants (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glucose 6-phosphate dehydrogenase) and the levels of non-enzymatic antioxidants, (reduced glutathione (GSH) and vitamin C) decreased, whereas, vitamin E increased in the erythrocytes of diabetic rats. Plasma hepatic marker enzymes also increased in STZ-diabetic rats. Oral administration of S. surattense leaf extract (100 mg kg-1 b.wt.) reversed these parameters towards normalcy. Thus, our results indicate that the S. surattense leaf extract possesses antihyperglycemic, antilipidperoxidative and hepatoprotective and antioxidant potential in diabetic rats.
  M. Sridevi , S. Senthil and K.V. Pugalendi
  In the present study, we have evaluated the validity of traditional usage of Solanum surattense as an antidiabetic agent. Adult male albino rats of Wistar strain, weighing 180-200 g, were made diabetic by administration of streptozotocin (STZ) (40 mg kg-1 body weight) intraperitoneally. In a dose determination study, alcoholic leaf extract of S. surattense at 100, 200 and 300 mg kg-1 body weight was orally administrated for 15 days and the extract at 100 mg dose significantly reduced blood glucose and also found to reduce the increased lipid peroxidation marker in diabetic rats. Extending oral administration of 100 mg kg-1 bw to diabetic rats, for 45 days, resulted in a significant decrease in blood glucose and an increase in plasma insulin level. In addition, diabetic rats showed significant reduction in the glycogen content and in the activities of glucose metabolizing enzymes such as glucokinase, glucose 6-phosphate dehydrogenase and an elevation in the activities of gluconeogeneic enzymes such as glucose-6-phosphatase and fructose-1, 6-bisphosphatase. S. surattense extract administration to diabetic rats reversed these changes in a significant manner. Thus, the results show that S. surattense possesses antihyperglycemic activity and provide evidence for its traditional usage in the control of diabetes.
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