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Articles by K.T. Odufuwa
Total Records ( 3 ) for K.T. Odufuwa
  B.A. Salau , W.E. Olooto , O.L. Adebayo , E.O. Ajani , K.T. Odufuwa and J.O. Olowookere
  Effects of various concentrations of sucrose diet were assessed on thirty weaning male albino rats divided randomly into five equal groups as follows: G1 (baseline group); G2 (control group given rat chow only); G3, G4 and G5 (groups with energy supply from sucrose at 10, 20 and 30%, respectively). The four groups were fed for twelve weeks and then fasted overnight. They were then anaesthetized with diethyl ether and venous blood was collected using cardio puncture method. Plasma was collected by centrifugation and total plasma cholesterol, HDL cholesterol and serum Triglycerides were assayed using Randox enzymatic kit while VLDL cholesterol, LDL cholesterol, Atherogenic index and coronary risk indices were calculated. Sucrose diet increased energy density. It also increased significantly (p<0.05). Plasma total cholesterol, LDL cholesterol, VLDL cholesterol, Triglycerides, Atherogenic and Coronary risk indices while it decreased HDL cholesterol. Present results indicated that sucrose diet at present level of consumption (about 25% energy supply) elevated cardiovascular risk factors in male albino rats and may predispose one to cardiovascular diseases.
  B.A. Salau , M.M. Adeyanju , K.T. Odufuwa and O. Osilesi
  Fruits and vegetables have been shown to contain vital components that moderate disease conditions. However, there is dearth of information of these effects in Africans diabetic subjects. Thus, we investigated the relative effect of fruits and vegetables on some selected heamorological factors associated with cardiovascular disease in diabetic subjects. Thirty diabetic subjects were selected at the cardiovascular clinic of Olabisi Onabanjo University Teaching Hospital, Sagamu, Nigeria. The subjects with mean Fasting Blood Glucose (FBG) level of 7.8±0.95 mmold L-1 were placed on 300 g of fruits and vegetables per day, while they continued their normal medication and food intake. A significant difference (p<0.05) was noticed between baseline and eight week values in all the parameters, Fibrinogen 262.75±2.64 to 250.57±3.98 mg dL-1, Blood viscosity, 5.96±0.21 to 4.82±0.23 m Pas; erythrocyte sedimentation rate 49.40±2.34 to 32.8±1.26 min h-1 and haematocrit 38.8±1.25 to 44.75±1.05%. At the eight week the fruits and vegetables were withdrawn for two weeks and the above parameters were reassessed (at the 10th week) which were compared with eight week values. Significant difference p<0.05 was noticed in E.S.R. 32.8±1.26 to 38.8±1.23. However no significant difference (p>0.05) was observed in haematocrit, 44.75±1.44 to 42.70±1.24, Fibrinogen, 254.5±3.98 to 250.57±3.16 mg dL-1. The results showed that regular intake of fruits and vegetables by diabetic subjects may reduce cardiovascular risk factors.
  T.B. Salau , A.K. Atunnise , K.T. Odufuwa , O.J. Avwioroko , C.A. Otuechere , O.D. Olukanni and B.A. Salau
  Background and Objective: The role of sucrose in the biochemical derangement in many tissues/organs has been established. However, there is a dearth of information about its effect on mineral status in integumentary tissues such as hair, nail, and skin in male albino rats. This study investigated minerals response in some selected integumentary tissues and possible implications on their integrity and performance in rats fed sucrose diet. Materials and Methods: Eighteen male albino rats were grouped into three with varying concentrations of sucrose supplying energy at 0% (G1), 10% (G2) and 20% (G3), respectively. Animals were fed for six months and the hair, nail and skin were harvested for calcium, phosphorus and magnesium analyses. Results: Substantial increase was observed in phosphorus and magnesium, while a decrease was noted in calcium levels in tissues as sucrose consumption increased. Conclusion: We opined that the alterations in mineral levels occasioned by sucrose concentration in the diet might adversely affect the integrity and function of integumentary tissues.
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