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Articles by K.O. Oyedeji
Total Records ( 10 ) for K.O. Oyedeji
  F.S. Oluwole and K.O. Oyedeji
  Aqueous extract of the leaf and stem of Portulaca oleracea (AEPO) was tested on isolated Guinea Pig Ileum (GPI) preparation. The extract was also tested on ileal smooth muscles of guinea pig precontracted with 10-5 g mL-1 carbachol and in vivo motility assessment in mice was investigated. The study showed the following order of sensitivity of GPI preparation to the drugs; AEPO> histamine> acetylcholine. Both atropine and promethazine abolished the contractile responses of GPI to AEPO only at low doses; 1x10-5 to 10-3 g mL-1 while nifedipine completely inhibited ileal muscle contractions to AEPO. The extract also caused relaxation to carbachol-sustained contractions. In vivo study demonstrated dose dependent reduction in peristaltic index in mice. From the results of these studies, the mechanism of action of the extract on relaxant response of GPI to AEPO may be dependent on Ca2+ antagonism.
  K.O. Oyedeji , A.F. Bolarinwa and A. Dare
  Tetracycline is a broad spectrum antibiotic produced by Streptomyces genus actinobacteria, indicated for use against many bacterial infections. Several studies have reported its effect on protein synthesis and teratogenicity but there is scanty information on its effect on male reproduction. This study was design to investigate the effect of this drug on serum testosterone level and sperm characteristic in male albino rats. Tetracycline (25 mg kg-1 bw) was administered for 30 days for andrological studies. Distilled water (0.5 mL) serves as the control. Serum testosterone level was assayed using Enzyme Link Immunosorbent Assay (ELISA) and semen analysis was done microscopically, histological analysis of the testis, kidney and liver were also carried out. Data were analysed using the student’s t-test at p<0.05. Treatment of rats for 30 days with 25 mg kg-1 bw of tetracycline caused significant decrease in testosterone (0.16 0.04 ng mL-1; relative to the control 1.38±0.53 ng mL-1). Treatment of rats with tetracycline caused significant decrease in sperm motility and sperm count relative to the control; while, there were no significant change in the values of sperm viability and percentage abnormal morphology relative to the control. There was interstitial oedema in the tests. The results from this study suggest that tetracycline has deleterious effect on male reproductive parameter of albino rats.
  K.O. Oyedeji , A.F. Bolarinwa and M.A. Hamzat
  Palm wine is the sap of a monocarpic crop (Rafia rafia) which is widely grown along the coast of West and Central Africa. Several studies have been reported on the effects of palm wine on fetal cerebral cortex but due to scanty information on its effects on androgenical studies, reproduction. These studies were designed to investigate the effects of palm wine on testosterone levels and reproductive parameters in Wistar albino rats. Fresh 50% diluted palm wine was administered orally for 30 days for reproductive studies at the dose of 10 mL kg-1 bw. Distilled water (0.5 mL) served as control. Testosterone level was assayed using ELISA, semen analysis were done microscopically. Histological analysis of the testis was also done. Data were analysed using students’ t-test at p<0.05. Treatment of rats with palm wine (10 mL kg-1 bw) caused no significant (p>0.05) increase in body weights of treated rats relative to control. Palm wine (10 mL kg-1 bw) caused significant decrease in testosterone level (0.12±0.02 ng mL-1; relative to control 1.38±0.52 ng mL-1). Palm wine (10 mL kg-1 bw) caused significant decrease in sperm counts, motility and viability but no significant change in morphology. There were interstistial congestion and odema of the testes.
  K.O. Oyedeji , A.F. Bolarinwa and A.A. Adedeji
  Cola nitida (Kola nut) is a caffeine-containing nut native to tropical North African and cultivated extensively in the new world tropics. Several studies have reported its effects on body weight and reduction in body fat without undesirable side effect as well as on gastric secretion but there is a dearth of information on its effect on reproduction. This study was designed to investigate the effect of its aqueous extract on reproductive parameters in male albino rats. Aqueous Extract of Cola nitida designated as AECON was prepared using cold maceration. The extract was administered for 30 days for andrological study. Distilled water (0.5 mL) served as the control. Plasma testosterone levels were assayed using ELISA and semen analysis was done microscopically, histology of the testis was done. Data was analysed using ANOVA at p<0.05. Treatment of rats with all doses of AECON caused significant decrease in testosterone levels, sperm motility, sperm viability and sperm count relative to the control but there was no significant change in sperm morphology. The testicular histopathological study revealed that there was moderate to severe necrosis with the dissolution of numerous seminiferous tubules in testis.
  K.O. Oyedeji , A.F. Bolarinwa and D.O. Owaduge
  The aim of this study was to investigate the effects of some alcoholic beverages (Gulder, Guiness, Chelsea, Rose-Daniel and Bacchus) on haematological and plasma biochemical parameters in male albino rats. Treatment of rats for 42 days with all the alcoholic beverages (except Gulder and Rose-Daniel) caused significant (p<0.05) increase in MCH value while treatment of rats with Guiness caused significant (p<0.05) decrease and increase in the neutrophil and lymphocyte values, respectively relative to their controls. Treatment of rats with all the alcoholic beverages caused no significant (p>0.05) changes in platelet, total WBC and RBC counts and some indices relating to it (Hb, PCV, MCV and MCHC) relative to their controls. Treatment of rats with all the alcoholic beverage caused significant (p<0.05) increase in total protein level relative to the control. Treatment of rats with all the alcoholic beverages (except Rose-Daniel) caused significant (p<0.05) increase in the activity of AST relative to the control while treatment of rats with all the alcoholic beverages (except Bacchus and Rose-Daniel) caused significant (p<0.05) increase in the activity of ALT relative to the control.
  K.O. Oyedeji and A.F. Bolarinwa
  The aim of this study was to investigate the effects of aqueous and methanolic extracts of Portulaca oleracea designated as AEPO and MEPO, respectively on estrous cycle and histopathology of the ovaries and uteri in female Albino rats. Treatments of rats for 21 days with 75 mg kg-1 BW AEPO produced no significant (p>0.05) change in the duration of all the phases of estrous cycle. Likewise, treatment of rats for 21 days with 75 mg kg-1 BW MEPO produced no significant (p>0.05) change in the duration of all the phases of estrous cycle. Treatment of rats for 25 days with 75 mg kg-1 BW AEPO and MEOP produced no significant (p>0.05) change in the ovarian and uterine weights of the treated rats relative to the control. Treatment of rats for 25 days with 75 mg kg-1 BW AEPO and MEPO induced no pathologic lesions or effects in both the ovaries and uteri of the treated rats. These findings indicate that AEPO and MEPO have no deleterious effects on the reproductive functions of female Albino rats.
  K.O. Oyedeji , A.F. Bolarinwa and A.A. Azeez
  Vernonia amygdalina is a shrub that grows throughout the tropical Africa. Several studies have reported the nutritional, anti-malaria and anti-helminthic effects of its extracts but there is scanty information on its effect on reproduction. This study was designed to investigate the effect of its methanolic extract on reproductive parameters in male Albino rats. Methanolic extract of Vernonia amygdalina is designated as MEVA. MEVA was prepared using cold maceration. The extract was administered for 30 days for andrological studies. Distilled water (0.5 mL) served as the control. Plasma testosterone levels were assayed using Enzyme-Link Immunosorbent Assay (ELISA) and semen analysis was done microscopically, histology of the testes was also done. Data were analyzed using ANOVA at p<0.05. Treatment of rats with all the doses of MEVA caused significant decrease in testosterone levels, sperm motility and sperm count relative to control; while, there was no significant change in sperm viability. MEVA also caused severe germinal erosion and necrosis in the seminiferous tubules in the testes.
  K.O. Oyedeji , A.F. Bolarinwa and O.A. Afolabi
  Tetracycline has been reported to be a broad-spectrum bacteriostatic autibiotics that inhibit protein synthesis but there is a dearth of information on its effect on blood chemistry and reproduction in female Albino rats. This study was designed to investigate the effect of this drug on haematological and reproductive parameters in female Albino rats. Tetracycline (5 mg kg-1 BW) was administered to the rats for 30 days for haematological and histopathological study and 21 days for estrous cycle study. Distilled water (0.5 mL) served as the control. Red Blood Cell (RBC) and Total White Blood Cell (TWBC) counts were determined using haemocytometer. Packed Cell Volume (PCV) was determine by micro-Haematocrit method. Differential leucocyte count was done using Schilling method. Vaginal smears were stained using the Papanicolaou’s staining technique. Routine histological technique was used in preparing the histological sections of the ovaries and uteri. Data were analysed using student’s t-test at p<0.05. Treatment of rats with tetracycline caused non-significant changes in RBC, TWBC, PCV and differential leucocyte values relative to their respective controls. Tetracycline caused significant decrease in the proestrous phase and a significant increase in the metestrous phase of the estrous cycle relative to their respective controls. However, it produced no pathological effect on the ovaries and uteri.
  K.O. Oyedeji , A.F. Bolarinwa and S.S. Ojeniran
  Paracetamol (Acetaminophen) is a widely used over the counter analgesic and antipyretic drugs. Several studies have reported the toxic, gastrointestinal and musculoskeletal effect of this drug but there is scanty information on its effect on blood chemistry and reproduction in Albino rats. This study was designed to investigate the effect of this drug on haematological and reproductive parameters in male Albino rats. Paracetamol (7.5 mg kg-1 BW) was administered to the rats for 42 days (6 weeks) for haematological and andrological study. Distilled water (0.5 mL) served as control. Red Blood Cell (RBC) and Total White Blood Cell (TWBC) counts were determined using haemocytometer. PCV was determined by micro-haematocrit method. Semen analyses were done microscopically. Data were analysed using student’s t-test at p<0.05. Treatment of rats with paracetamol caused decrease in PCV and RBC counts relative to the controls. Treatment of rats with paracetamol also caused significant decrease in sperm motility and sperm count but did not produce any pathological lesions on the testes.
  K.O. Oyedeji , A.F. Bolarinwa and A.K. Adigun
  Aspirin is an organic acid (Acetyl chloride and sodium salicylate used anciently as an anti-clotting agent that reduces the risk of clotting diseases but there is a dearth of information on its effects on androgenic studies histology of the testes, kidneys and livers and reproductions. This study was designed to investigate the effects of aspirin on reproductive parameters and histopathological changes in male Albino rats. Aqueous diluted aspirin was administered orally for 30 days for androgenic and reproductive studies at the dose of 10 mg mL-1 BW. Distilled water (0.05 mL) served as control. Testosterone level was assayed using ELISA, semen analysis were done microscopically. Histology of the testis, kidney and liver was done. Data were analysed using students t-test at p<0.05. Treatment with aspirin 10 mg mL-1 BW caused no significant (p>0.05) increases in body weights of treated rats, relative to control. Aspirin 10 mg mL-1 BW caused significant decrease in testosterone levels and sperm count. Aspirin caused no significant changes in sperm viability but significant increase in abnormal sperm morphology. It caused no visible lesion in the germinal epithelium.
 
 
 
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